Broad‐Spectrum Antiviral Agents Based on Multivalent Inhibitors of Viral Infectivity
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202001433
Abstract: Abstract The ongoing pandemic of the coronavirus disease (Covid‐19), caused by the spread of the severe acute respiratory syndrome coronavirus 2 (SARS CoV‐2), highlights the need for broad‐spectrum antiviral drugs. In this Essay, it is… read more here.
Keywords: multivalent inhibitors; spectrum antiviral; inhibitors viral; broad spectrum ... See more keywords
Expanding the activity spectrum of antiviral agents.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.04.006
Abstract: Broad-spectrum antivirals (BSAs) are agents that inhibit replication of several human viruses. Here, we review 108 approved, investigational, and experimental BSAs, for which safety profiles in humans are available. The most effective and tolerable BSAs… read more here.
Keywords: expanding activity; activity spectrum; antiviral agents; spectrum antiviral ... See more keywords
Clofazimine derivatives as potent broad-spectrum antiviral agents with dual-target mechanism
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2022.114209
Abstract: Thirty-two clofazimine derivatives, of which twenty-two were new, were synthesized and evaluated for their antiviral effects against both rabies virus and pseudo-typed SARS-CoV-2, taking clofazimine (1) as the lead. Among them, compound 15f bearing 4-methoxy-2-pyridyl… read more here.
Keywords: spectrum antiviral; broad spectrum; clofazimine derivatives; derivatives potent ... See more keywords
A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01481
Abstract: The naturally occurring nucleotide 3'-deoxy-3',4'-didehydro-cytidine-5'-triphosphate (ddhCTP) was recently found to exert potent and broad-spectrum antiviral activity. However, nucleoside 5'-triphosphates in general are not cell-permeable, which precludes the direct use of ddhCTP as a therapeutic. To… read more here.
Keywords: chemical strategy; broad spectrum; antiviral nucleotide; spectrum antiviral ... See more keywords
Host Proteins Identified in Extracellular Viral Particles as Targets for Broad-Spectrum Antiviral Inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00204
Abstract: Liquid chromatography mass spectrometry (LCMS) proteomic analyses have revealed that host proteins are often captured in extracellular virions. These proteins may play a role in viral replication or infectivity and can represent targets for broad-spectrum… read more here.
Keywords: spectrum antiviral; host proteins; host; targets broad ... See more keywords
NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00668
Abstract: DNA viruses are responsible for many diseases in humans. Current treatments are often limited by toxicity, as in the case of cidofovir (CDV, Vistide), a compound used against cytomegalovirus (CMV) and adenovirus (AdV) infections. CDV… read more here.
Keywords: antiviral potency; bioavailability; npp 669; spectrum antiviral ... See more keywords
Computational screening of known broad-spectrum antiviral small organic molecules for potential influenza HA stem inhibitors
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DOI: 10.1371/journal.pone.0203148
Abstract: Background With the emergence of new influenza virus strains that are resistant to current inhibitors such as oseltamivir (anti-neuraminidase (NA)) and amantadine (anti-M2 proton channel), influenza A viruses continue to be a serious threat to… read more here.
Keywords: spectrum antiviral; screening known; computational screening; stem ... See more keywords
Broad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042060
Abstract: The COVID-19 pandemic has evidenced the urgent need for the discovery of broad-spectrum antiviral therapies that could be deployed in the case of future emergence of novel viral threats, as well as to back up… read more here.
Keywords: peptide; activity amphibian; spectrum antiviral; activity ... See more keywords
Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Viruses"
DOI: 10.3390/v11020173
Abstract: Viral gastroenteritis is an important cause of morbidity and mortality worldwide, being particularly severe for children under the age of five. The most common viral agents of gastroenteritis are noroviruses, rotaviruses, sapoviruses, astroviruses and adenoviruses,… read more here.
Keywords: spectrum antiviral; diarrhea causing; polymerase; viral polymerase ... See more keywords
Development of Broad-Spectrum Antiviral Agents—Inspiration from Immunomodulatory Natural Products
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DOI: 10.3390/v13071257
Abstract: Developing broad-spectrum antiviral drugs remains an important issue as viral infections continue to threaten public health. Host-directed therapy is a method that focuses on potential targets in host cells or the body, instead of viral… read more here.
Keywords: natural products; broad spectrum; development broad; spectrum antiviral ... See more keywords
A Short 5′triphosphate RNA nCoV-L Induces a Broad-Spectrum Antiviral Response by Activating RIG-I
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14112451
Abstract: Small molecular nucleic acid drugs produce antiviral effects by activating pattern recognition receptors (PRRs). In this study, a small molecular nucleotide containing 5′triphosphoric acid (5′PPP) and possessing a double-stranded structure was designed and named nCoV-L.… read more here.
Keywords: triphosphate rna; broad spectrum; short triphosphate; spectrum antiviral ... See more keywords