Phage display identification of nanomolar ligands for human NEDD4-WW3: Energetic and dynamic implications for the development of broad-spectrum antivirals.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.03.010
Abstract: The recognition of PPxY viral Late domains by the third WW domain of the human HECT-E3 ubiquitin ligase NEDD4 (NEDD4-WW3) is essential for the budding of many viruses. Blocking these interactions is a promising strategy… read more here.
Keywords: affinity; spectrum antivirals; identification; broad spectrum ... See more keywords
Molecular tweezers - a new class of potent broad-spectrum antivirals against enveloped viruses.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06737k
Abstract: A new supramolecular approach to broad spectrum antivirals utilizes host guest chemistry between molecular tweezers and lysine/arginine as well as choline. Basic amino acids in amyloid-forming SEVI peptides (semen-derived enhancers of viral infection) are included… read more here.
Keywords: spectrum antivirals; molecular tweezers; new class; tweezers new ... See more keywords
DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs)
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac348
Abstract: Abstract Viruses can cross species barriers and cause unpredictable outbreaks in man with substantial economic and public health burdens. Broad-spectrum antivirals, (BSAs, compounds inhibiting several human viruses), and BSA-containing drug combinations (BCCs) are deemed as… read more here.
Keywords: spectrum antivirals; drugvirus info; containing drug; bsa containing ... See more keywords
Toward wide-spectrum antivirals against coronaviruses: Molecular characterization of SARS-CoV-2 NSP13 helicase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj4526
Abstract: Molecular dynamics simulations are used to unravel the SARS-CoV-2 NSP13 behavior in interaction with natural ligands and inhibitors. read more here.
Keywords: spectrum antivirals; cov nsp13; wide spectrum; antivirals coronaviruses ... See more keywords
Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.948553
Abstract: Considering the significant impact of the recent COVID-19 outbreak, development of broad-spectrum antivirals is a high priority goal to prevent future global pandemics. Antiviral development processes generally emphasize targeting a specific protein from a particular… read more here.
Keywords: lead molecules; protease; cov2 3clpro; spectrum antivirals ... See more keywords
Broad-Spectrum Antivirals and Antiviral Drug Combinations
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14020301
Abstract: Viral diseases consistently pose a substantial economic and public health burden worldwide [...]. read more here.
Keywords: drug combinations; antiviral drug; broad spectrum; antivirals antiviral ... See more keywords
Broad-Spectrum Antivirals Derived from Natural Products
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15051100
Abstract: Scientific advances have led to the development and production of numerous vaccines and antiviral drugs, but viruses, including re-emerging and emerging viruses, such as SARS-CoV-2, remain a major threat to human health. Many antiviral agents… read more here.
Keywords: spectrum antivirals; natural products; derived natural; antiviral drugs ... See more keywords