The mutational spectrum of SARS-CoV-2 genomic and antigenomic RNA
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2022.1747
Abstract: The raw material for viral evolution is provided by intra-host mutations occurring during replication, transcription or post-transcription. Replication and transcription of Coronaviridae proceed through the synthesis of negative-sense ‘antigenomes’ acting as templates for positive-sense genomic… read more here.
Keywords: strand; spectrum sars; rna; mutational spectrum ... See more keywords
Atypical Mutational Spectrum of SARS-CoV-2 Replicating in the Presence of Ribavirin
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01315-22
Abstract: We report that ribavirin exerts an inhibitory and mutagenic activity on SARS-CoV-2-infecting Vero cells, with a therapeutic index higher than 10. Deep sequencing analysis of the mutant spectrum of SARS-CoV-2 replicating in the absence or… read more here.
Keywords: spectrum sars; cov replicating; ribavirin; presence ribavirin ... See more keywords