A Catalytic Asymmetric Pictet–Spengler Platform as a Biomimetic Diversification Strategy toward Naturally Occurring Alkaloids
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DOI: 10.1021/jacs.2c06664
Abstract: Tetrahydroisoquinoline (THIQ) alkaloids constitute a large and diverse class of bioactive natural products, with the parent compounds and related downstream biosynthetic secondary metabolites spanning thousands of isolated structures. Chemoenzymatic synthetic approaches toward the relevant THIQs… read more here.
Keywords: asymmetric pictet; pictet spengler; spengler platform; catalytic asymmetric ... See more keywords