Novel mutations in FSIP2 lead to multiple morphological abnormalities of the sperm flagella and poor ICSI prognosis.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145536
Abstract: Multiple morphological abnormalities of the sperm flagella (MMAF) is defined as deformities that cause sperm motility disorders, further resulting in male infertility. However, the reported genes related to sperm flagellar defects can only explain approximately… read more here.
Keywords: morphological abnormalities; abnormalities sperm; sperm flagella; novel mutations ... See more keywords
Novel Biallelic DNAH1 Variations Cause Multiple Morphological Abnormalities of the Sperm Flagella.
Sign Up to like & getrecommendations! Published in 2021 at "DNA and cell biology"
DOI: 10.1089/dna.2021.0097
Abstract: Sperm motility is vital to human reproduction, and malformed sperm flagella can cause male infertility. Individuals with multiple morphological abnormalities of the flagella mostly have absent, short, coiled, bent, and/or irregular-caliber flagella. In this study,… read more here.
Keywords: morphological abnormalities; novel biallelic; microscopy; sperm flagella ... See more keywords
Flow-induced buckling dynamics of sperm flagella.
Sign Up to like & getrecommendations! Published in 2019 at "Physical Review E"
DOI: 10.1103/physreve.100.063107
Abstract: The swimming sperm of many external fertilizing marine organisms face complex fluid flows during their search for egg cells. Aided by chemotaxis, relatively weak flows are known to enhance sperm-egg fertilization rates through hydrodynamic guidance.… read more here.
Keywords: sperm flagella; flow; dynamics sperm; buckling dynamics ... See more keywords
Biallelic mutations of CFAP58 are associated with multiple morphological abnormalities of the sperm flagella
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Genetics"
DOI: 10.1111/cge.13898
Abstract: Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe type of teratozoospermia. In this study, whole‐exome sequencing was conducted on 55 patients with MMAF, and biallelic mutations of CFAP58 were identified in two… read more here.
Keywords: morphological abnormalities; abnormalities sperm; sperm flagella; multiple morphological ... See more keywords
Absence of CEP78 causes photoreceptor and sperm flagella impairments in mice and a human individual
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.76157
Abstract: Cone-rod dystrophy (CRD) is a genetically inherited retinal disease that can be associated with male infertility, while the specific genetic mechanisms are not well known. Here, we report CEP78 as a causative gene of a… read more here.
Keywords: cep78; sperm flagella; male infertility; absence cep78 ... See more keywords