Molecular investigation on the interaction of spermine with proteinase K by multispectroscopic techniques and molecular simulation studies.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2016.10.038
Abstract: The alteration in structure, function and stability of proteinase K in the presence of spermine was investigated using spectroscopic methods and simulation techniques. The stability and enzyme activity of proteinase K-spermine complex were significantly enhanced… read more here.
Keywords: molecular investigation; spermine; proteinase; investigation interaction ... See more keywords
Colorimetric detection of spermine and spermidine by zincon in aqueous solution
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151302
Abstract: Abstract The anionic organic dye, zincon, was found to be a colorimetric probe for spermine and spermidine at pH 4.0 in pure aqueous solution through its aggregation by electrostatic interactions with them. The addition of… read more here.
Keywords: zincon; spermine; spermine spermidine; aqueous solution ... See more keywords
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-97069-x
Abstract: Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for… read more here.
Keywords: spermine; mendelian randomization; cancer; smox ... See more keywords
Regulation of sucrose synthase and its association with grain filling in spermine-treated rice plant under water deficit
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Plant Interactions"
DOI: 10.1080/17429145.2019.1657189
Abstract: ABSTRACT Spermine (SPM) was utilized to investigate its impact on the accumulation of sucrose synthase (SUS) and the role of SUS as a predictor of sink strength of rice under cyclic water stress. Treatments which… read more here.
Keywords: spermine; rice; sucrose synthase; grain filling ... See more keywords
Urinary spermine level as novel additional diagnostic marker of prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz343.023
Abstract: Abstract Background prostate cancer (PC) is one of the most common male cancer in the world, and it is one of the leading causes of mortality and momentous public health impact in many developed countries.… read more here.
Keywords: spermine; prostate cancer; marker; test ... See more keywords
Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx277
Abstract: The mucopolysaccharidoses (MPS) are rare genetic disorders marked by severe somatic and neurological symptoms. Development of treatments for the neurological manifestations of MPS has been hindered by the lack of objective measures of central nervous… read more here.
Keywords: spermine; biomarker; disease; pathogenesis ... See more keywords
Spermine inhibits PAMP-induced ROS and Ca2+ burst and reshapes the transcriptional landscape of PAMP-triggered immunity in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erac411
Abstract: Abstract Polyamines are small polycationic amines whose levels increase during defense. Previous studies support the contribution of the polyamine spermine to defense responses. However, the potential contribution of spermine to pathogen-associated molecular pattern (PAMP)-triggered immunity… read more here.
Keywords: spermine; triggered immunity; spermine inhibits; inhibits pamp ... See more keywords
Transcriptomics Coupled to Proteomics Reveals Novel Targets for the Protective Role of Spermine in Diabetic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5909378
Abstract: Background Diabetic cardiomyopathy (DbCM) is the main complication and the cause of high mortality of diabetes. Exploring the transcriptomics and proteomics of DbCM is of great significance for understanding the biology of the disease and… read more here.
Keywords: metabolism; dbcm; spermine; amino acid ... See more keywords
Spermine modulates fungal morphogenesis and activates plasma membrane H+-ATPase during yeast to hyphae transition
Sign Up to like & getrecommendations! Published in 2018 at "Biology Open"
DOI: 10.1242/bio.029660
Abstract: ABSTRACT Polyamines play a regulatory role in eukaryotic cell growth and morphogenesis. Despite many molecular advances, the underlying mechanism of action remains unclear. Here, we investigate a mechanism by which spermine affects the morphogenesis of… read more here.
Keywords: spermine; fungal morphogenesis; transition; atpase ... See more keywords
Simple fluorescence optosensing probe for spermine based on ciprofloxacin-Tb3+ complexation
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0251306
Abstract: We developed a facile detection method of spermine based on the fluorescence (FL) quenching of the ciprofloxacin-Tb3+ complex, which shows astrong green emission. Ciprofloxacin (CP) makes efficient bondings to Tb3+ ion as a linker molecule… read more here.
Keywords: spermine; fluorescence; probe; spermine based ... See more keywords
Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1061570
Abstract: Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma that includes fusion-positive (FP) and fusion-negative (FN) molecular subtypes. FP-RMS expresses PAX3-FOXO1 fusion protein and often shows dismal prognosis. FN-RMS shows cytogenetic abnormalities and frequently harbors… read more here.
Keywords: fusion; spermine; dna damage; fusion negative ... See more keywords