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   Articles with "spermine" as a keyword



Induced Self‐Assembly of Vitamin E‐Spermine/siRNA Nanocomplexes via Spermine/Helix Groove‐Specific Interaction for Efficient siRNA Delivery and Antitumor Therapy

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202303186

Abstract: Gene therapy has been one of potential strategies for the treatment of different diseases, where efficient and safe gene delivery systems are also extremely in need. Current lipid nanoparticles (LNP) technology highly depends on the… read more here.

Keywords: sirna delivery; delivery; self assembled; spermine ... See more keywords

Molecular investigation on the interaction of spermine with proteinase K by multispectroscopic techniques and molecular simulation studies.

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recommendations! Published in 2017 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2016.10.038

Abstract: The alteration in structure, function and stability of proteinase K in the presence of spermine was investigated using spectroscopic methods and simulation techniques. The stability and enzyme activity of proteinase K-spermine complex were significantly enhanced… read more here.

Keywords: molecular investigation; spermine; proteinase; investigation interaction ... See more keywords

Colorimetric detection of spermine and spermidine by zincon in aqueous solution

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recommendations! Published in 2019 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2019.151302

Abstract: Abstract The anionic organic dye, zincon, was found to be a colorimetric probe for spermine and spermidine at pH 4.0 in pure aqueous solution through its aggregation by electrostatic interactions with them. The addition of… read more here.

Keywords: zincon; spermine; spermine spermidine; aqueous solution ... See more keywords

Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-97069-x

Abstract: Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for… read more here.

Keywords: spermine; mendelian randomization; cancer; smox ... See more keywords

Molecular basis of TRPV3 channel blockade by intracellular polyamines

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-08103-x

Abstract: ThermoTRPV1-4 channels are involved in the regulation of multiple physiological processes, including thermo- and pain perception, thermoregulation, itch, and nociception and therefore tight control of their activity is a critical requirement for correct perception of… read more here.

Keywords: blockade; intracellular polyamines; trpv3; spermine ... See more keywords

Regulation of sucrose synthase and its association with grain filling in spermine-treated rice plant under water deficit

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recommendations! Published in 2019 at "Journal of Plant Interactions"

DOI: 10.1080/17429145.2019.1657189

Abstract: ABSTRACT Spermine (SPM) was utilized to investigate its impact on the accumulation of sucrose synthase (SUS) and the role of SUS as a predictor of sink strength of rice under cyclic water stress. Treatments which… read more here.

Keywords: spermine; rice; sucrose synthase; grain filling ... See more keywords

Urinary spermine level as novel additional diagnostic marker of prostate cancer

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recommendations! Published in 2019 at "Annals of Oncology"

DOI: 10.1093/annonc/mdz343.023

Abstract: Abstract Background prostate cancer (PC) is one of the most common male cancer in the world, and it is one of the leading causes of mortality and momentous public health impact in many developed countries.… read more here.

Keywords: spermine; prostate cancer; marker; test ... See more keywords

Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis

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recommendations! Published in 2017 at "Human Molecular Genetics"

DOI: 10.1093/hmg/ddx277

Abstract: The mucopolysaccharidoses (MPS) are rare genetic disorders marked by severe somatic and neurological symptoms. Development of treatments for the neurological manifestations of MPS has been hindered by the lack of objective measures of central nervous… read more here.

Keywords: spermine; biomarker; disease; pathogenesis ... See more keywords

Spermine inhibits PAMP-induced ROS and Ca2+ burst and reshapes the transcriptional landscape of PAMP-triggered immunity in Arabidopsis

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recommendations! Published in 2022 at "Journal of Experimental Botany"

DOI: 10.1093/jxb/erac411

Abstract: Abstract Polyamines are small polycationic amines whose levels increase during defense. Previous studies support the contribution of the polyamine spermine to defense responses. However, the potential contribution of spermine to pathogen-associated molecular pattern (PAMP)-triggered immunity… read more here.

Keywords: spermine; triggered immunity; spermine inhibits; inhibits pamp ... See more keywords

Intracellular Ca 2+ Levels and Mitochondrial Bioenergetics in Proximal Tubule Cells Are Affected by Polyamines

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recommendations! Published in 2025 at "Physiology"

DOI: 10.1152/physiol.2025.40.s1.0599

Abstract: Background: Polyamines are molecules with multiple amino groups; primary polyamines found in mammals are putrescine, spermidine, and spermine. Polyamines are involved in cell proliferation, redox balance, apoptosis, and regulatory interactions with nucleic acids. Dysregulation of… read more here.

Keywords: physiology; mitochondrial bioenergetics; calcium; spermine ... See more keywords

Transcriptomics Coupled to Proteomics Reveals Novel Targets for the Protective Role of Spermine in Diabetic Cardiomyopathy

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/5909378

Abstract: Background Diabetic cardiomyopathy (DbCM) is the main complication and the cause of high mortality of diabetes. Exploring the transcriptomics and proteomics of DbCM is of great significance for understanding the biology of the disease and… read more here.

Keywords: metabolism; dbcm; spermine; amino acid ... See more keywords