In Vivo Behavior of Ultrasmall Spherical Nucleic Acids.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202300097
Abstract: The biological properties of spherical nucleic acids (SNAs) are largely independent of nanoparticle core identity but significantly affected by oligonucleotide surface density. Additionally, the payload-to-carrier (i.e., DNA-to-nanoparticle) mass ratio of SNAs is inversely proportional to… read more here.
Keywords: nanoparticle; like properties; vivo behavior; spherical nucleic ... See more keywords
Cascaded DNA circuits-programmed self-assembly of spherical nucleic acids for high signal amplification
Sign Up to like & getrecommendations! Published in 2019 at "Science China Chemistry"
DOI: 10.1007/s11426-019-9603-3
Abstract: Signal amplification is an important issue in DNA nanotechnology and molecular diagnostics. In this work, we report a strategy for the catalytic self-assembly of spherical nucleic acids (SNAs) programmed by two-layer cascaded DNA circuits through… read more here.
Keywords: spherical nucleic; self assembly; dna; assembly spherical ... See more keywords
An enzyme-free surface plasmon resonance imaging biosensing method for highly sensitive detection of microRNA based on catalytic hairpin assembly and spherical nucleic acid.
Sign Up to like & getrecommendations! Published in 2020 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.02.055
Abstract: MicroRNAs (miRNAs), considered as therapeutic targets and biomarkers, play important roles in biological processes. Herein, an enzyme-free surface plasmon resonance imaging (SPRi) biosensing method has been developed for miRNA detection based on catalytic hairpin assembly… read more here.
Keywords: spherical nucleic; surface; hairpin; biosensing method ... See more keywords
A Spherical Nucleic Acid Probe Based on Au-Se Bond.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c01204
Abstract: Spherical nucleic acid probes (SNAPs) are 3D nucleic acid nanostructures with multiple superiorities over bare nucleic acid chains. Au based SNAPs that employ gold nanoparticles (AuNPs) as cores, densely modified nucleic acid chains (commonly via… read more here.
Keywords: spherical nucleic; bond; acid chains; acid ... See more keywords
Hairpin-Spherical Nucleic Acids for Diagnosing COVID-19: a Simple Method to Generalize the Conventional PCR for Molecular Assays
Sign Up to like & getrecommendations! Published in 2021 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.1c01515
Abstract: The COVID-19 pandemic revealed during the first global wave of this infectious disease that mass diagnostic testing was necessary to more rapidly detect infection in patients and control the pandemic. Therefore, extra research efforts to… read more here.
Keywords: spherical nucleic; nucleic acids; method; pcr ... See more keywords
Framework and Spherical Nucleic Acids Synergistically Enhanced Electrochemiluminescence Nanosensors for Rapidly Diagnosing Acute Myocardial Infarction Based on Circulating MicroRNA Levels.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03144
Abstract: Acute myocardial infarction (AMI)-related microRNAs (miRNAs) in circulating blood have been proved as promising biomarkers for AMI diagnosis. The detection of these miRNAs at ultralow levels usually requires nucleic acid amplification strategies to improve the… read more here.
Keywords: myocardial infarction; spherical nucleic; detection; ami ... See more keywords
Spherical Nucleic Acid Probe Based on 2'-Fluorinated DNA Functionalization for High-Fidelity Intracellular Sensing.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04294
Abstract: Traditional spherical nucleic acids (SNAs) based on gold nanoparticles (AuNPs) assembled through Au-S covalent bonds are widely used in DNA-programmable assembly, biosensing, imaging, and therapeutics. However, biological thiols and other chemical substances can break the… read more here.
Keywords: fluorinated dna; based fluorinated; spherical nucleic; acid probe ... See more keywords
Automated nanoplasmonic analysis of spherical nucleic acids clusters in single cells.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b04500
Abstract: Spherical nucleic acids (SNAs) have been extensively used in the field of biosensing, drug delivery and theranostics. Precise engineering of SNAs and their clinical application require better understanding of their cellular internalization process. We demonstrate… read more here.
Keywords: spherical nucleic; nucleic acids; analysis; clustering states ... See more keywords
Polyethylenimine-Spherical Nucleic Acid Nanoparticles against Gli1 Reduce the Chemoresistance and Stemness of Glioblastoma Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00707
Abstract: Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with nearly 100% of patients ultimately succumbing to the disease. Median patient survival is 15 months, and no standard of care currently… read more here.
Keywords: nucleic acid; spherical nucleic; gli1 reduce; acid nanoparticles ... See more keywords
Maximizing TLR9 Activation in Caner Immunotherapy with Dual-Adjuvanted Spherical Nucleic Acids.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c00723
Abstract: Nucleic-acid-based immune adjuvants have been extensively investigated for the design of cancer vaccines. However, nucleic acids often require the assistance of a carrier system to improve cellular uptake. Yet, such systems are prone to carrier-associated… read more here.
Keywords: activation caner; maximizing tlr9; spherical nucleic; tlr9 activation ... See more keywords
Facile Strategy for Visible Disassembly of Spherical Nucleic Acids Programmed by Catalytic DNA Circuits.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b02107
Abstract: The programmable toehold-mediated DNA-strand-displacement reaction has demonstrated its extraordinary capability in driving the spherical nucleic acid assembly. Here, a facile strategy of integrating a DNA-strand-displacement-based DNA circuit with a universal spherical nucleic acid aggregate system… read more here.
Keywords: spherical nucleic; dna; disassembly spherical; visible disassembly ... See more keywords