Engineering Liquid Hierarchical Materials with DNA‐Programmed Spherical Nucleic Acids
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202504471
Abstract: Inspired by nature, the orchestration of self‐assembling building blocks into hierarchical superstructures offers a transformative approach to functional materials design. While significant advances have been made in engineering solid‐state hierarchical materials such as crystals and… read more here.
Keywords: spherical nucleic; hierarchical materials; engineering; liquid hierarchical ... See more keywords
Advanced Synthesis of Spherical Nucleic Acids: A Limit‐Pursuing Game with Broad Implications
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400976
Abstract: Spherical nucleic acids (SNAs) consist of DNA strands arranged radially and packed densely on the surface of nanoparticles. Due to their unique properties, which are not found in naturally occurring linear or circular DNA, SNAs… read more here.
Keywords: spherical nucleic; broad implications; advanced synthesis; synthesis spherical ... See more keywords
In Vivo Behavior of Ultrasmall Spherical Nucleic Acids.
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DOI: 10.1002/smll.202300097
Abstract: The biological properties of spherical nucleic acids (SNAs) are largely independent of nanoparticle core identity but significantly affected by oligonucleotide surface density. Additionally, the payload-to-carrier (i.e., DNA-to-nanoparticle) mass ratio of SNAs is inversely proportional to… read more here.
Keywords: nanoparticle; like properties; vivo behavior; spherical nucleic ... See more keywords
From Structure to Application: The Evolutionary Trajectory of Spherical Nucleic Acids.
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DOI: 10.1002/smll.202310026
Abstract: Since the proposal of the concept of spherical nucleic acids (SNAs) in 1996, numerous studies have focused on this topic and have achieved great advances. As a new delivery system for nucleic acids, SNAs have… read more here.
Keywords: spherical nucleic; structure application; application evolutionary; evolutionary trajectory ... See more keywords
Smart Stimuli-Responsive Spherical Nucleic Acids: Cutting-Edge Platforms for Biosensing, Bioimaging, and Therapeutics.
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DOI: 10.1002/smll.202310732
Abstract: Spherical nucleic acids (SNAs) with exceptional colloidal stability, multiple modularity, and programmability are excellent candidates to address common molecular delivery-related issues. Based on this, the higher targeting accuracy and enhanced controllability of stimuli-responsive SNAs render… read more here.
Keywords: spherical nucleic; biosensing bioimaging; responsive snas; bioimaging therapeutics ... See more keywords
Cascaded DNA circuits-programmed self-assembly of spherical nucleic acids for high signal amplification
Sign Up to like & getrecommendations! Published in 2019 at "Science China Chemistry"
DOI: 10.1007/s11426-019-9603-3
Abstract: Signal amplification is an important issue in DNA nanotechnology and molecular diagnostics. In this work, we report a strategy for the catalytic self-assembly of spherical nucleic acids (SNAs) programmed by two-layer cascaded DNA circuits through… read more here.
Keywords: spherical nucleic; self assembly; dna; assembly spherical ... See more keywords
An enzyme-free surface plasmon resonance imaging biosensing method for highly sensitive detection of microRNA based on catalytic hairpin assembly and spherical nucleic acid.
Sign Up to like & getrecommendations! Published in 2020 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.02.055
Abstract: MicroRNAs (miRNAs), considered as therapeutic targets and biomarkers, play important roles in biological processes. Herein, an enzyme-free surface plasmon resonance imaging (SPRi) biosensing method has been developed for miRNA detection based on catalytic hairpin assembly… read more here.
Keywords: spherical nucleic; surface; hairpin; biosensing method ... See more keywords
A Spherical Nucleic Acid Probe Based on Au-Se Bond.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c01204
Abstract: Spherical nucleic acid probes (SNAPs) are 3D nucleic acid nanostructures with multiple superiorities over bare nucleic acid chains. Au based SNAPs that employ gold nanoparticles (AuNPs) as cores, densely modified nucleic acid chains (commonly via… read more here.
Keywords: spherical nucleic; bond; acid chains; acid ... See more keywords
Hairpin-Spherical Nucleic Acids for Diagnosing COVID-19: a Simple Method to Generalize the Conventional PCR for Molecular Assays
Sign Up to like & getrecommendations! Published in 2021 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.1c01515
Abstract: The COVID-19 pandemic revealed during the first global wave of this infectious disease that mass diagnostic testing was necessary to more rapidly detect infection in patients and control the pandemic. Therefore, extra research efforts to… read more here.
Keywords: spherical nucleic; nucleic acids; method; pcr ... See more keywords
Framework and Spherical Nucleic Acids Synergistically Enhanced Electrochemiluminescence Nanosensors for Rapidly Diagnosing Acute Myocardial Infarction Based on Circulating MicroRNA Levels.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03144
Abstract: Acute myocardial infarction (AMI)-related microRNAs (miRNAs) in circulating blood have been proved as promising biomarkers for AMI diagnosis. The detection of these miRNAs at ultralow levels usually requires nucleic acid amplification strategies to improve the… read more here.
Keywords: myocardial infarction; spherical nucleic; detection; ami ... See more keywords
Spherical Nucleic Acid Probe Based on 2'-Fluorinated DNA Functionalization for High-Fidelity Intracellular Sensing.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04294
Abstract: Traditional spherical nucleic acids (SNAs) based on gold nanoparticles (AuNPs) assembled through Au-S covalent bonds are widely used in DNA-programmable assembly, biosensing, imaging, and therapeutics. However, biological thiols and other chemical substances can break the… read more here.
Keywords: fluorinated dna; based fluorinated; spherical nucleic; acid probe ... See more keywords