Vascularization of iNSC spheroid in a 3D spheroid-on-a-chip platform enhances neural maturation.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.27978
Abstract: In vitro platforms for studying the human brain have been developed, and brain organoids derived from stem cells have been studied. However, current organoid models lack three-dimensional (3D) vascular networks, limiting organoid proliferation, differentiation, and… read more here.
Keywords: vascularization insc; spheroid; insc spheroid; platform ... See more keywords
All‐in‐one microfluidic design to integrate vascularized tumor spheroid into high‐throughput platform
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28221
Abstract: The development of a scalable and highly reproducible in vitro tumor microenvironment (TME) platform still sheds light on new insights into cancer metastasis mechanisms and anticancer therapeutic strategies. Here, we present an all‐in‐one injection molded… read more here.
Keywords: high throughput; spheroid; vascularized tumor; tumor ... See more keywords
Comparison of Drug Inhibitory Effects ([Formula: see text]) in Monolayer and Spheroid Cultures.
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of mathematical biology"
DOI: 10.1007/s11538-020-00746-7
Abstract: Traditionally, the monolayer (two-dimensional) cell cultures are used for initial evaluation of the effectiveness of anticancer drugs. In particular, these experiments provide the [Formula: see text] curves that determine drug concentration that can inhibit growth… read more here.
Keywords: spheroid; monolayer; drug; see text ... See more keywords
Integrative In Situ Photodynamic Therapy-Induced Cell Death Measurement of 3D-Bioprinted MCF-7 Tumor Spheroids.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03022
Abstract: The development of new in vitro models that closely mimic the tumor microenvironment (TME) to evaluate the efficacy of anticancer drugs has received great attention. In this study, a three-dimensional (3D) bioprinted Michigan Cancer Foundation-7… read more here.
Keywords: integrative situ; spheroid; tumor spheroids; photodynamic therapy ... See more keywords
MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity
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DOI: 10.1038/s41592-021-01291-4
Abstract: Spheroids are three-dimensional cellular models with widespread basic and translational application across academia and industry. However, methodological transparency and guidelines for spheroid research have not yet been established. The MISpheroID Consortium developed a crowdsourcing knowledgebase… read more here.
Keywords: spheroid; mispheroid knowledgebase; tool; experimental parameters ... See more keywords
Numerical simulation of water exit of an initially fully submerged buoyant spheroid in an axisymmetric flow
Sign Up to like & getrecommendations! Published in 2017 at "Fluid Dynamics Research"
DOI: 10.1088/1873-7005/aa747b
Abstract: The free water exit of an initially fully submerged buoyant spheroid in an axisymmetric flow, which is driven by the difference between the vertical fluid force and gravity, is investigated. The fluid is assumed to… read more here.
Keywords: spheroid; water; water exit; flow ... See more keywords
The 14th FDR prize
Sign Up to like & getrecommendations! Published in 2021 at "Fluid Dynamics Research"
DOI: 10.1088/1873-7005/ac2ef2
Abstract: Steady flow in a rapidly rotating spheroid with weak precession: I Shigeo Kida Vol. 52, No. 1, 015513 (2020) The flow in a rotating spheroidal container that executes precession has long attracted attention as a… read more here.
Keywords: spheroid; angular velocity; velocity; solution ... See more keywords
Overexpression of aldolase, fructose‐bisphosphate C and its association with spheroid formation in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Pathology International"
DOI: 10.1111/pin.13200
Abstract: Colorectal cancer (CRC) is a leading cause of cancer‐related death worldwide. The spheroid colony formation assay is a useful method to identify cancer stem cells (CSCs). Using the DLD‐1 and WiDr CRC cell lines, we… read more here.
Keywords: cancer; fructose bisphosphate; spheroid; aldolase fructose ... See more keywords
Quantitative and Qualitative Image Analysis of In Vitro Co-Culture 3D Tumor Spheroid Model by Employing Image-Processing Techniques
Sign Up to like & getrecommendations! Published in 2021 at "Applied Sciences"
DOI: 10.3390/app11104636
Abstract: This work proposes a novel region-estimation (RE) algorithm using the quantification of colon-cancer (HCT-8) and fibroblasts (NIH3T3) cells to estimate the densest region of colon-cancer cells in in vitro 3D co-cultured spheroids. Cells were labelled… read more here.
Keywords: region; spheroid; cell; image ... See more keywords
Differential Angiogenic Potential of 3-Dimension Spheroid of HNSCC Cells in Mouse Xenograft
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22158245
Abstract: The experimental animal model is still essential in the development of new anticancer drugs. We characterized mouse tumors derived from two-dimensional (2D) monolayer cells or three-dimensional (3D) spheroids to establish an in vivo model with… read more here.
Keywords: spheroid; monolayer; differential angiogenic; hnscc cells ... See more keywords