Near‐Infrared Emissive Super Penetrating Conjugated Polymer Dots for Intratumoral Imaging in 3D Tumor Spheroid Models
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202403398
Abstract: This study describes the formation of single‐chain polymer dots (Pdots) via ultrasonic emulsification of nonionic donor‐acceptor‐donor type (D–A–D) alkoxy thiophene–benzobisthiadiazole‐based conjugated polymers (Poly BT) with amphiphilic cetyltrimethylammonium bromide (CTAB). The methodology yields Pdots with a… read more here.
Keywords: tumor spheroid; tumor; polymer dots; spheroid models ... See more keywords
A Microfluidics-Assisted Double-Barreled Nanobioconjugate Synthesis Introducing Aprotinin as a New Moonlight Nanocarrier Protein: Tested toward Physiologically Relevant 3D-Spheroid Models.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c16548
Abstract: Proteins are promising substances for introducing new drug carriers with efficient blood circulation due to low possibilities of clearance by macrophages. However, such natural biopolymers have highly sophisticated molecular structures, preventing them from being assembled… read more here.
Keywords: carrier; protein; drug; physiologically relevant ... See more keywords
Abstract 6465: Development of triple co-culture spheroid models of lung and ovarian carcinomas for in vitro evaluation of antitumor therapies
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6465
Abstract: Tumor spheroids have emerged as superior in vitro models for studying solid tumors compared to monolayer cultures due to their ability to replicate key aspects of the tumor microenvironment (TME), including cell-cell interactions, extracellular matrix… read more here.
Keywords: lung ovarian; culture; tumor; culture spheroid ... See more keywords
Recapitulating Glioma Stem Cell Niches Using 3D Spheroid Models for Glioblastoma Research
Sign Up to like & getrecommendations! Published in 2024 at "Biosensors"
DOI: 10.3390/bios14110539
Abstract: Glioblastoma multiforme (GBM) is among the most aggressive brain cancers, and it contains glioma stem cells (GSCs) that drive tumor initiation, progression, and recurrence. These cells resist conventional therapies, contributing to high recurrence rates in… read more here.
Keywords: glioma stem; stem cell; stem; gbm ... See more keywords
Narciclasine as a Novel Treatment for Lung Cancer and Malignant Pleural Mesothelioma: Insights from 3D Tumor Spheroid Models
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms262010127
Abstract: Thoracic tumors, including lung adenocarcinoma (LUAD) and malignant pleural mesothelioma (MM), remain a leading cause of cancer-related deaths, primarily due to the challenges in treating advanced thoracic tumors. New drugs with optimal efficacy and minimal… read more here.
Keywords: lung; malignant pleural; pleural mesothelioma; spheroid models ... See more keywords
Quantum Dots Mediated Imaging and Phototherapy in Cancer Spheroid Models: State of the Art and Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14102136
Abstract: Quantum Dots (QDs) are fluorescent nanoparticles known for their exceptional optical properties, i.e., high fluorescence emission, photostability, narrow emission spectrum, and broad excitation wavelength. These properties make QDs an exciting choice for bioimaging applications, notably… read more here.
Keywords: cell; quantum dots; state art; imaging phototherapy ... See more keywords