Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition.
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DOI: 10.1016/j.toxlet.2021.07.012
Abstract: Non-dialysable protein-bound uremic toxins (PBUTs) contribute to the development of cardiovascular disease (CVD) in chronic kidney disease (CKD) and vice versa. PBUTs have been shown to alter sphingolipid imbalance. Dihydroceramide desaturase 1 (Des1) is an… read more here.
Keywords: uremic toxins; sphingolipid imbalance; inhibition; dihydroceramide desaturase ... See more keywords