Nanosecond pulsed electric field ablation-induced modulation of sphingolipid metabolism is associated with Ly6c2+ mononuclear phagocyte differentiation in liver cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13372
Abstract: Preclinical studies have proven that nanosecond pulsed electric field (nsPEF) ablation can be a safe and effective treatment for humans with unresectable liver cancer that are ineligible for thermal ablation. The concomitant activation of antitumor… read more here.
Keywords: sphingolipid metabolism; nanosecond pulsed; liver cancer; ablation ... See more keywords
MicroRNA‐520c‐3p impacts sphingolipid metabolism mediating PI3K/AKT signaling in NSCLC: Systems perspective
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30319
Abstract: Increasing research suggests that sphingolipid metabolism is essential for the progression and metastasis of cancer. The underlying mechanistic insight into the dysregulation of sphingolipid metabolism affecting pathways is poorly investigated. As a result, the goal… read more here.
Keywords: metabolism; sphingolipid metabolism; pi3k akt; microrna 520c ... See more keywords
Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1040-x
Abstract: Sphingolipid signaling disturbances correlate with Alzheimer’s disease (AD) progression. We examined the influence of FTY720/fingolimod, a sphingosine analog and sphingosine-1-phosphate (S1P) receptor modulator, on the expression of sphingolipid metabolism and signaling genes in a mouse… read more here.
Keywords: expression sphingolipid; alzheimer disease; sphingolipid metabolism; model ... See more keywords
Novel Sphingolipid‐Based Cancer Therapeutics in the Personalized Medicine Era: CHAPTER TWELVE
Sign Up to like & getrecommendations! Published in 2018 at "Advances in Cancer Research"
DOI: 10.1016/bs.acr.2018.04.016
Abstract: Abstract Sphingolipids are bioactive lipids that participate in a wide variety of biological mechanisms, including cell death and proliferation. The myriad of pro‐death and pro‐survival cellular pathways involving sphingolipids provide a plethora of opportunities for… read more here.
Keywords: medicine; sphingolipid based; sphingolipid metabolism; cancer ... See more keywords
Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2017.03.016
Abstract: Background Hidradenitis suppurativa (HS) is a debilitating skin disease characterized by painful recurrent nodules and abscesses caused by chronic inflammation. Early events in the development of HS are believed to occur in the folliculopilosebaceous unit;… read more here.
Keywords: gene expression; expression; expression sphingolipid; sphingolipid metabolism ... See more keywords
Residue of thiram in food, suppresses immune system stress signals and disturbs sphingolipid metabolism in chickens.
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2022.110415
Abstract: Thiram, a well-known sulfur containing organic compound is frequently and extensively used in agriculture because of high biological activity to control different pests. In certain cases, due to long persistence in the environment pesticides and… read more here.
Keywords: sphingolipid metabolism; thiram food; suppresses immune; residue thiram ... See more keywords
Diversity in Sphingolipid Metabolism across Land Plants.
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DOI: 10.1093/jxb/erab558
Abstract: Sphingolipids are essential metabolites found in all plant species. They are required for plasma membrane integrity, tolerance of and responses to biotic and abiotic stresses, and intracellular signalling. There is extensive diversity in the sphingolipid… read more here.
Keywords: sphingolipid metabolism; across land; diversity sphingolipid; metabolism across ... See more keywords
Role of sphingolipid metabolism in neurodegeneration
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15044
Abstract: Sphingolipids are a class of lipids highly enriched in the central nervous system (CNS), which shows great diversity and complexity, and has been implicated in CNS development and function. Alterations in sphingolipid metabolism have been… read more here.
Keywords: metabolism; role sphingolipid; metabolism neurodegeneration; sphingolipid metabolism ... See more keywords
Dysregulated sphingolipid metabolism contributes to NASH-HCC disease progression
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734514
Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is the fastest-rising cause of end-stage liver disease for liver transplantation. The underlying mechanisms of NAFLD disease progression from nonalcoholic steatohepatitis (NASH) to hepatocellular carcinoma (HCC) remain unclear. It… read more here.
Keywords: sphingolipid metabolism; disease; nash hcc; hcc ... See more keywords
Chronic Cerebral Hypoperfusion Aggravates Parkinson's Disease Dementia-Like Symptoms and Pathology in 6-OHDA-Lesioned Rat through Interfering with Sphingolipid Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5392966
Abstract: Chronic cerebral hypoperfusion (CCH) is a cardinal risk factor for Parkinson's disease dementia (PDD), but this potential causality lacks mechanistic evidence. We selected bilateral common carotid artery occlusion (BCCAO) to simulate chronic cerebral hypoperfusion in… read more here.
Keywords: metabolism; sphingolipid metabolism; chronic cerebral; parkinson disease ... See more keywords
Sphingolipid Metabolism and Signaling in Lung Cancer: A Potential Therapeutic Target
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/9099612
Abstract: Sphingolipids are important bioactive lipids that not only play an important role in maintaining the barrier function and fluidity of cell membranes but also regulate multiple processes in cancer development by controlling multiple signaling pathways… read more here.
Keywords: lung cancer; sphingolipid metabolism; metabolism signaling; cancer ... See more keywords