Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of endocrinology"
DOI: 10.1093/ejendo/lvac007
Abstract: OBJECTIVE Adrenocortical carcinomas (ACCs) are invasive tumours arising in the adrenal cortex, and steroidogenic tumours are associated with worse prognostic outcomes. Loss-of-function mutations in sphingosine-1-phosphate lyase (SGPL1) cause primary adrenal insufficiency and as a key… read more here.
Keywords: phosphate lyase; sphingosine phosphate; sgpl1; patient survival ... See more keywords
Dissecting the regulatory roles of ORM proteins in the sphingolipid pathway of plants.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS computational biology"
DOI: 10.1371/journal.pcbi.1008284
Abstract: Sphingolipids are a vital component of plant cellular endomembranes and carry out multiple functional and regulatory roles. Different sphingolipid species confer rigidity to the membrane structure, facilitate trafficking of secretory proteins, and initiate programmed cell… read more here.
Keywords: network; pathway; sphingolipid pathway; regulatory roles ... See more keywords
Sphingolipid pathway enzymes modulate cell fate and immune responses.
Sign Up to like & getrecommendations! Published in 2017 at "Immunotherapy"
DOI: 10.2217/imt-2017-0089
Abstract: Sphingolipids (SLs) are a class of essential, bioactive lipids. The SL family includes over 4000 distinct molecules, characterized by their sphingoid base (long-chain aliphatic amine) backbone. SLs are key components of cell membranes, yet their… read more here.
Keywords: enzymes modulate; pathway enzymes; sphingolipid pathway; cell fate ... See more keywords