Sphingosine kinase and sphingosine-1-phosphate regulate epithelial cell architecture by the modulation of de novo sphingolipid synthesis
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DOI: 10.1371/journal.pone.0213917
Abstract: Sphingolipids regulate several aspects of cell behavior and it has been demonstrated that cells adjust their sphingolipid metabolism in response to metabolic needs. Particularly, sphingosine-1-phosphate (S1P), a final product of sphingolipid metabolism, is a potent… read more here.
Keywords: sphingolipid synthesis; novo sphingolipid; sphingosine; sphingosine phosphate ... See more keywords
The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.51067
Abstract: Sphingolipids are membrane and bioactive lipids that are required for many aspects of normal mammalian development and physiology. However, the importance of the regulatory mechanisms that control sphingolipid levels in these processes is not well… read more here.
Keywords: synthesis pathway; ormdl; ormdl genes; sphingolipid synthesis ... See more keywords