Sphingomyelin and progression of renal and coronary heart disease in individuals with type 1 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetologia"
DOI: 10.1007/s00125-020-05201-9
Abstract: Lipid abnormalities are associated with diabetic kidney disease and CHD, although their exact role has not yet been fully explained. Sphingomyelin, the predominant sphingolipid in humans, is crucial for intact glomerular and endothelial function. Therefore,… read more here.
Keywords: disease; type diabetes; chd; sphingomyelin ... See more keywords
Sphingomyelin Acyl Chains Influence the Formation of Sphingomyelin- and Cholesterol-Enriched Domains.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.11.001
Abstract: Abstract The segregation of lipids into lateral membrane domains has been extensively studied. It is well established that the structural differences between phospholipids play an important role in lateral membrane organization. When a high enough… read more here.
Keywords: cholesterol enriched; formation; acyl chains; enriched domains ... See more keywords
The enzymatic sphingomyelin to ceramide conversion increases the shear membrane viscosity at the air-water interface.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in colloid and interface science"
DOI: 10.1016/j.cis.2017.07.014
Abstract: Whereas most of lipids have viscous properties and they do not have significant elastic features, ceramides behave as very rigid solid assemblies, displaying viscoelastic behaviour at physiological temperatures. The present review addresses the surface rheology… read more here.
Keywords: viscosity; interface; enzymatic sphingomyelin; ceramide ... See more keywords
Transbilayer Movement of Sphingomyelin Precedes Catastrophic Breakage of Enterobacteria-Containing Vacuoles
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.05.083
Abstract: Summary Pathogenic bacteria enter the cytosol of host cells through uptake into bacteria-containing vacuoles (BCVs) and subsequent rupture of the vacuolar membrane [1]. Bacterial invaders are sensed either directly, through cytosolic pattern-recognition receptors specific for… read more here.
Keywords: sphingomyelin; bcv rupture; transbilayer movement; containing vacuoles ... See more keywords
Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.04.067
Abstract: Sphingomyelin synthase (SMS) is a membrane enzyme that catalyzes the synthesis of sphingomyelin, is required for the maintenance of plasma membrane microdomain fluidity, and has two isoforms: SMS1 and SMS2. Although these isoforms exhibit the… read more here.
Keywords: sms2 inhibitors; sms2; sphingomyelin synthase; sphingomyelin ... See more keywords
The relationship among amyloid-β deposition, sphingomyelin level, and the expression and function of P-glycoprotein in Alzheimer’s disease pathological process
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.358607
Abstract: In Alzheimer’s disease, the transporter P-glycoprotein is responsible for the clearance of amyloid-β in the brain. Amyloid-β correlates with the sphingomyelin metabolism, and sphingomyelin participates in the regulation of P-glycoprotein. The amyloid cascade hypothesis describes… read more here.
Keywords: glycoprotein; sphingomyelin; alzheimer disease; age ... See more keywords
Sphingolipids: Friends or Foes?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Atherosclerosis and Thrombosis"
DOI: 10.5551/jat.ed192
Abstract: Sphingolipids play a physiologically major role in the human body. They not only serve as essential constituents of the membrane but also make microdomains called lipid rafts with cholesterol on the cell surface for transporting… read more here.
Keywords: sphingomyelin; sphingosine; cer; sphingosine cer ... See more keywords