Sphingomyelin synthase 2 loss suppresses steatosis but exacerbates fibrosis in the liver of mice fed with choline-deficient, L-amino acid-defined, high-fat diet.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.09.142
Abstract: Sphingomyelin synthase 2 (SMS2) regulates sphingomyelin synthesis and contributes to obesity and hepatic steatosis. Here, we investigated the effect of SMS2 deficiency on liver fibrosis in mice fed with choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD)… read more here.
Keywords: fed choline; sms2 deficiency; steatosis; sphingomyelin synthase ... See more keywords
Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors.
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DOI: 10.1016/j.ejmech.2017.04.067
Abstract: Sphingomyelin synthase (SMS) is a membrane enzyme that catalyzes the synthesis of sphingomyelin, is required for the maintenance of plasma membrane microdomain fluidity, and has two isoforms: SMS1 and SMS2. Although these isoforms exhibit the… read more here.
Keywords: sms2 inhibitors; sms2; sphingomyelin synthase; sphingomyelin ... See more keywords
Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor.
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DOI: 10.1016/j.ejmech.2018.12.028
Abstract: The sphingomyelin synthase 2 (SMS2) is a potential target for pharmacological intervention in atherosclerosis. However, so far, few selective SMS2 inhibitors and their pharmacological activities were reported. In this study, a class of 2-benzyloxybenzamides were… read more here.
Keywords: inhibitor; novel selective; anti atherosclerotic; atherosclerotic activities ... See more keywords
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
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DOI: 10.1101/2022.04.02.486804
Abstract: Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway. This gradient marks a fundamental… read more here.
Keywords: sphingomyelin synthase; sms2; sms2 variants; secretory pathway ... See more keywords
Sphingomyelin synthase 1 regulates the epithelial-to-mesenchymal transition mediated by the TGF-β/Smad pathway in MDA-MB-231 cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.9722
Abstract: Breast cancer is the most common cancer in women and a leading cause of cancer-associated mortalities in the world. Epithelial-to-mesenchymal transition (EMT) serves an important role in the process of metastasis and invasive ability in… read more here.
Keywords: 231 cells; mesenchymal transition; mda 231; tgf smad ... See more keywords