Articles with "sphingomyelinase" as a keyword



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Mechanistic characterization and inhibition of sphingomyelinase C over substituted Iron Schiff bases of chitosan adsorbed on glassy carbon electrode.

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Published in 2017 at "Chemico-biological interactions"

DOI: 10.1016/j.cbi.2016.12.021

Abstract: The medical treatment of laxoscelisms is based solely on supportive measures. Although equine antiserum for Sphingomyelinase C (SMASE) and D isomers are available, it is not used due to the risk of an anaphylactic reaction… read more here.

Keywords: glassy carbon; schiff bases; adsorbed glassy; bases chitosan ... See more keywords
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Consensus recommendation for a diagnostic guideline for acid sphingomyelinase deficiency

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Published in 2017 at "Genetics in Medicine"

DOI: 10.1038/gim.2017.7

Abstract: Disclaimer:This diagnostic guideline is intended as an educational resource and represents the opinions of the authors, and is not representative of recommendations or policy of the American College of Medical Genetics and Genomics (ACMG). The… read more here.

Keywords: sphingomyelinase; diagnostic guideline; acid sphingomyelinase; sphingomyelinase deficiency ... See more keywords

Membrane bending and sphingomyelinase-associated, sulfatide-dependent hypoxic adhesion of sickle mature erythrocytes

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Published in 2023 at "Blood Advances"

DOI: 10.1182/bloodadvances.2022008392

Abstract: Key Points • Bending stress exerted on the plasma membrane by sickle hemoglobin polymerization enhances sulfatide-mediated adhesion of mature erythrocytes in SCD.• Inflammatory sphingomyelinase activity could result in abnormal adhesion and membrane damage in sickle… read more here.

Keywords: adhesion; sphingomyelinase; mature erythrocytes; sickle mature ... See more keywords
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Characterization of a Neutral Sphingomyelinase Activity in Human Serum and Plasma

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Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24032467

Abstract: Alterations of sphingolipids and their metabolizing enzymes play a role in various diseases. However, peripheral biomarkers for such changes are limited. Particularly, in the increasingly reported involvement of neutral sphingomyelinase (NSM) with four described isoforms… read more here.

Keywords: activity human; serum; nsm activity; neutral sphingomyelinase ... See more keywords

Alkaline sphingomyelinase (NPP7) in hepatobiliary diseases: A field that needs to be closely studied

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Published in 2018 at "World Journal of Hepatology"

DOI: 10.4254/wjh.v10.i2.246

Abstract: Alkaline sphingomyelinase cleaves phosphocholine from sphingomyelin, platelet-activating factor, lysophosphatidylcholine, and less effectively phosphatidylcholine. The enzyme shares no structure similarities with acid or neutral sphingomyelinase but belongs to ecto-nucleotide pyrophosphatase/phosphodiesterase (NPP) family and therefore is also… read more here.

Keywords: hepatobiliary diseases; alkaline sphingomyelinase; sphingomyelinase; npp7 hepatobiliary ... See more keywords