Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation
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DOI: 10.3390/ijms232213935
Abstract: Flavivirus comprises globally emerging and re-emerging pathogens such as Zika virus (ZIKV), Dengue virus (DENV), and West Nile virus (WNV), among others. Although some vaccines are available, there is an unmet medical need as no… read more here.
Keywords: neutral sphingomyelinase; activity; binding site; sphingomyelinase nsmase2 ... See more keywords