1576-P: Neutral Sphingomyelinase 2 (nSMase2) Regulates Insulin Synthesis, Secretion, and Glucose Sensing
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DOI: 10.2337/db25-1576-p
Abstract: Introduction and Objective: Neutral sphingomyelinase 2 (nSMase2) is a crucial enzyme involved in several important cellular processes, including exosome formation, ceramide production, cellular stress responses, and inflammatory signaling responses. However, impacts on beta cell health… read more here.
Keywords: insulin synthesis; neutral sphingomyelinase; insulin; sphingomyelinase nsmase2 ... See more keywords
Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213935
Abstract: Flavivirus comprises globally emerging and re-emerging pathogens such as Zika virus (ZIKV), Dengue virus (DENV), and West Nile virus (WNV), among others. Although some vaccines are available, there is an unmet medical need as no… read more here.
Keywords: neutral sphingomyelinase; activity; binding site; sphingomyelinase nsmase2 ... See more keywords