Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis
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DOI: 10.1194/jlr.m080374
Abstract: Inhibiting the glutamate/cystine antiporter system xc−, a key antioxidant defense machinery in the CNS, could trigger a novel form of regulated necrotic cell death, ferroptosis. The underlying mechanisms of system xc−-dependent cell demise were elucidated… read more here.
Keywords: system; glutamate induced; sphingomyelinase promotes; glutamate ... See more keywords