Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104452
Abstract: SPHK1 (sphingosine kinase-1) catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P), is found to be highly expressed in solid tumors. Here, extracellular vesicles (EVs) are identified as the key transporters of SPHK1 to the tumor… read more here.
Keywords: tumor; tumor microenvironment; s1p; sphingosine ... See more keywords
Evaluation of chiral N,N-dimethyl-sphingosine for the interaction between nerve growth factor and tropomyosin receptor kinase A.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23433
Abstract: Neuropathic pain is an unbearable condition caused by nervous system damage. As distinct acute pain, neuropathic pain is chronic, and it severely influences quality of life. N,N-Dimethyl-d-erythro-sphingosine (DMS), a neuropathic pain inducer, is metabolited de… read more here.
Keywords: dimethyl; sphingosine; nerve; factor ... See more keywords
A Phase 1 First‐in‐Human Single‐Ascending‐Dose Trial With ESB1609, a Selective Agonist to the Sphingosine‐1‐Phosphate Receptor 5
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1256
Abstract: ESB1609 is a small‐molecule sphingosine‐1‐phosphate‐5 receptor–selective agonist designed to restore lipid homeostasis by promoting cytosolic egress of sphingosine‐1‐phosphate to reduce abnormal levels of ceramide and cholesterol in disease. A phase 1 study was conducted in… read more here.
Keywords: csf; esb1609; phosphate receptor; sphingosine ... See more keywords
Translocation and activation of sphingosine kinase 1 by ceramide‐1‐phosphate
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27818
Abstract: Sphingosine kinases (SphKs) and ceramide kinase (CerK) phosphorylate sphingosine to sphingosine‐1‐phosphate (S1P) and ceramide to ceramide‐1‐phosphate (C1P), respectively. S1P and C1P are bioactive lipids that regulate cell fate/function and human health/diseases. The translocation and activity… read more here.
Keywords: sphk1; ceramide; c1p; translocation ... See more keywords
Enhanced phosphorylation of sphingosine and ceramide sustains the exuberant proliferation of endothelial progenitors in Kaposi sarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2ma0817-312r
Abstract: Endothelial colony‐forming cells (ECFCs), a unique endothelial stem cell population, are highly increased in the blood of Kaposi sarcoma (KS) patients. KS‐derived ECFCs (KS‐ECFCs) are also endowed with increased proliferative and vasculogenic potential, thus suggesting… read more here.
Keywords: kaposi sarcoma; proliferation; sphingosine; s1p ... See more keywords
Sphingosine‐1‐phosphate related signalling pathways manipulating virus replication
Sign Up to like & getrecommendations! Published in 2023 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.2415
Abstract: Viruses can create a unique cellular environment that facilitates replication and transmission. Sphingosine kinases (SphKs) produce sphingosine‐1‐phosphate (S1P), a bioactive sphingolipid molecule that performs both physiological and pathological effects primarily by activating a subgroup of… read more here.
Keywords: replication; sphingosine; signalling pathways; virus ... See more keywords
The role of sphingosine 1-phosphate metabolism in bone and joint pathologies and ectopic calcification.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.115087
Abstract: Sphingolipids display important functions in various pathologies such as cancer, obesity, diabetes, cardiovascular or neurodegenerative diseases. Sphingosine, sphingosine 1-phosphate (S1P), and ceramide are the central molecules of sphingolipid metabolism. Sphingosine kinases 1 and 2 (SK1… read more here.
Keywords: metabolism; calcification; bone joint; sphingosine ... See more keywords
Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01508
Abstract: The sphingosine-1-phosphate (S1P) signaling pathway is an attractive drug target due to its involvement in immune cell chemotaxis and vascular integrity. The formation of S1P is catalyzed by sphingosine kinase 1 or 2 (SphK1 or… read more here.
Keywords: potency selectivity; sphingosine kinase; inhibitor; potency ... See more keywords
A Small Molecule Fluorogenic Probe for the Detection of Sphingosine in Living Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c06652
Abstract: The single-chained sphingolipid sphingosine is an essential structural lipid and signaling molecule. Abnormal sphingosine metabolism is observed in several diseases, including cancer, diabetes, and Alzheimer's. Despite its biological importance, there is a lack of tools… read more here.
Keywords: probe; small molecule; sphingosine living; sphingosine ... See more keywords
Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungs
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DOI: 10.1038/s41598-021-97708-3
Abstract: Ex-vivo lung perfusion (EVLP) systems like XVIVO are more and more common in the setting of lung transplantation, since marginal donor-lungs can easily be subjected to a performance test or be treated with corticosteroids or… read more here.
Keywords: sphingosine adverse; isolated ventilated; lung; sphingosine ... See more keywords
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2007856117
Abstract: Significance Hepatic insulin resistance is a chief pathogenic determinant in the development of type 2 diabetes, which is often associated with abnormal hepatic lipid regulation. Sphingolipids are a class of essential lipids in the liver,… read more here.
Keywords: insulin; hepatic insulin; glucose homeostasis; sphk2 ... See more keywords