Investigation of guanidinium chloride-induced unfolding pathway of sphingosine kinase 1.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.01.023
Abstract: Sphingosine kinase 1 (SphK1) is a lipid kinase which plays vital role in the regulation of varieties of biological processes including, cell growth, apoptosis and mitogenesis. In the present study, we investigated the guanidinium chloride… read more here.
Keywords: sphingosine kinase; guanidinium chloride; kinase; induced unfolding ... See more keywords
Sphingosine kinase inhibitor, SKI-II confers protection against the ionizing radiation by maintaining redox homeostasis most likely through Nrf2 signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119543
Abstract: Exposure to ionizing radiation (IR) set a series of deleterious events causing acute radiation syndrome and mortality, posing the need for a potent and safe radio-protective drug. IR induces cell death predominantly by causing oxidative… read more here.
Keywords: sphingosine kinase; radiation; ionizing radiation; cell ... See more keywords
Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01508
Abstract: The sphingosine-1-phosphate (S1P) signaling pathway is an attractive drug target due to its involvement in immune cell chemotaxis and vascular integrity. The formation of S1P is catalyzed by sphingosine kinase 1 or 2 (SphK1 or… read more here.
Keywords: potency selectivity; sphingosine kinase; inhibitor; potency ... See more keywords
Discovery of Harmaline as a Potent Inhibitor of Sphingosine Kinase-1: A Chemopreventive Role in Lung Cancer
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c02165
Abstract: The sphingosine kinase-1/sphingosine-1-phosphate pathway is linked with the cancer progression and survival of the chemotherapy-challenged cells. Sphingosine kinase-1 (SphK1) has emerged as an attractive drug target, but their inhibitors from natural sources are limited. In… read more here.
Keywords: kinase; lung cancer; sphingosine kinase; harmaline ... See more keywords
Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death Discovery"
DOI: 10.1038/cddiscovery.2017.47
Abstract: Sphingosine kinase 1 (SphK1) overexpressed in head and neck squamous cell carcinoma (SCC) regulates tumor growth. The effects of PF-543, a specific SphK1 inhibitor, on human SCC cells were examined. The proportion of viable cells… read more here.
Keywords: neck squamous; sphingosine kinase; scc; cell ... See more keywords
The anti-osteosarcoma cell activity by the sphingosine kinase 1 inhibitor SKI-V
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00838-4
Abstract: Sphingosine kinase 1 (SphK1) expression and activity are elevated in human osteosarcoma (OS) and is a promising target of therapy. SKI-V is a non-competitive and highly-efficient non-lipid SphK1 inhibitor. The potential anti-OS cell activity by… read more here.
Keywords: sphingosine kinase; primary cells; cell activity; inhibitor ... See more keywords
Identification of sphingosine kinase 1 as a therapeutic target in B‐lineage acute lymphoblastic leukaemia
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15097
Abstract: Craig T. Wallington‐Beddoe, Vicki Xie, Daochen Tong, Jason A. Powell, Alexander C. Lewis, Lorena Davies, Stuart M. Pitson, Kenneth F. Bradstock Linda J. Bendall read more here.
Keywords: sphingosine kinase; target lineage; lineage acute; kinase therapeutic ... See more keywords
Effect of sphingosine kinase modulators on interleukin‐1β release, sphingosine 1‐phosphate receptor 1 expression and experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13670
Abstract: The sphingosine analogue, FTY720 (GilenyaR), alleviates clinical disease progression in multiple sclerosis. Here, we variously assessed the effects of an azide analogue of (S)‐FTY720 vinylphosphonate (compound 5; a sphingosine kinase 1 activator), (R)‐FTY720 methyl ether… read more here.
Keywords: sphingosine kinase; autoimmune encephalomyelitis; sphingosine; sphingosine phosphate ... See more keywords
Sphingosine kinase activity and sphingosine-1-phosphate in the inflamed human periodontium.
Sign Up to like & getrecommendations! Published in 2021 at "Oral diseases"
DOI: 10.1111/odi.13995
Abstract: OBJECTIVES This study evaluated changes in the levels of Sphingosine-1-Phosphate (S1P) and Sphingosine Kinase (SPHK) activity in response to non-surgical periodontal treatment in humans. METHODS Diseased (n=65) and healthy sites (n=72) were screened in 18… read more here.
Keywords: sphingosine kinase; treatment; sphingosine phosphate; non surgical ... See more keywords
The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Emergency Medicine International"
DOI: 10.1155/2022/6716143
Abstract: The aim of the study is to investigate the expression of sphingosine kinase 1 (SPHK1) and vascular endothelial growth factor (VEGF) in patients with endometrial carcinoma and its clinical significance. The tissues of 86 cases… read more here.
Keywords: patients endometrial; sphingosine kinase; endometrial carcinoma; expression ... See more keywords
Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022016112
Abstract: Hematopoietic stem cells (HSCs) have reduced capacities to properly maintain and replenish the hematopoietic system during myelosuppressive injury or aging. Expanding and rejuvenating HSCs for therapeutic purposes has been a long-sought goal, with limited progress.… read more here.
Keywords: hscs; sphingosine kinase; hematopoietic stem; improving metabolic ... See more keywords