Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204396119
Abstract: Significance Sphingolipids and cholesterol are important constituents of membranes. Very little is known how their metabolism is cross-regulated and how this affects membrane contact sites (MCS) that control lipid traffic. Here, we report deletion of… read more here.
Keywords: endocytic organelles; contacts late; late endocytic; kinases regulate ... See more keywords
Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments.
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DOI: 10.2174/1381612825666190404115424
Abstract: BACKGROUND Sphingosine kinases (SphKs) catalyze the phosphorylation of sphingosine to form the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). S1P is an important lipid mediator with a wide range of biological functions; it is also involved in… read more here.
Keywords: sphk1 sphk2; design sphingosine; inhibitors challenges; sphingosine ... See more keywords
The Impact of Sphingosine Kinases on Inflammation-Induced Cytokine Release and Vascular Endothelial Barrier Integrity
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DOI: 10.3390/ijms232112848
Abstract: Sphingosine kinases type 1 and 2 (SphK1/2) are required for the production of the immune modulator sphingosine 1-phosphate (S1P). SphK1 deficient mice (SphK1−/−) revealed 50% reduced S1P in plasma, while SphK2−/− mice demonstrated 2–3 times… read more here.
Keywords: inflammation; cytokine; sphingosine kinases; mice ... See more keywords