Sphingosine‐1‐phosphate‐lyase deficiency affects glucose metabolism in a way that abets oncogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13300
Abstract: Sphingosine‐1‐phosphate (S1P), a bioactive signaling lipid, is involved in several vital processes, including cellular proliferation, survival and migration, as well as neovascularization and inflammation. Its critical role in the development and progression of cancer is… read more here.
Keywords: metabolism; s1p; glucose metabolism; lyase ... See more keywords
A Phase 1 First‐in‐Human Single‐Ascending‐Dose Trial With ESB1609, a Selective Agonist to the Sphingosine‐1‐Phosphate Receptor 5
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1256
Abstract: ESB1609 is a small‐molecule sphingosine‐1‐phosphate‐5 receptor–selective agonist designed to restore lipid homeostasis by promoting cytosolic egress of sphingosine‐1‐phosphate to reduce abnormal levels of ceramide and cholesterol in disease. A phase 1 study was conducted in… read more here.
Keywords: csf; esb1609; phosphate receptor; sphingosine ... See more keywords
Cardiac Safety of Ozanimod, a Novel Sphingosine‐1‐Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.383
Abstract: Ozanimod is a novel, selective, oral sphingosine‐1‐phosphate (1 and 5) receptor modulator in development for multiple sclerosis and inflammatory bowel disease. This randomized, double‐blind, placebo‐controlled, positive‐controlled, parallel‐group thorough QT study characterized the effects of ozanimod… read more here.
Keywords: cardiac safety; sphingosine phosphate; phosphate receptor; receptor modulator ... See more keywords
Cytokine‐Induced and Stretch‐Induced Sphingosine 1‐Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3844
Abstract: Spondyloarthritis (SpA) is a common rheumatic disease characterized by enthesis inflammation (enthesitis) and ectopic ossification (enthesophytes). The current pathogenesis model suggests that inflammation and mechanical stress are both strongly involved in SpA pathophysiology. We have… read more here.
Keywords: spondyloarthritis; abnormal ossification; enthesis; ossification ... See more keywords
Hyperglycemia‐Triggered Sphingosine‐1‐Phosphate and Sphingosine‐1‐Phosphate Receptor 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization
Sign Up to like & getrecommendations! Published in 2019 at "Liver Transplantation"
DOI: 10.1002/lt.25470
Abstract: Hyperglycemia aggravates hepatic ischemia/reperfusion injury (IRI), but the underlying mechanism for the aggravation remains elusive. Sphingosine‐1‐phosphate (S1P) and sphingosine‐1‐phosphate receptors (S1PRs) have been implicated in metabolic and inflammatory diseases. Here, we discuss whether and how… read more here.
Keywords: polarization; ischemia reperfusion; hyperglycemia; sphingosine phosphate ... See more keywords
Activation mechanisms of the first sphingosine‐1‐phosphate receptor
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3165
Abstract: Activation of the first sphingosine‐1‐phosphate receptor (S1PR1) promotes permeability of the blood brain barrier, astrocyte and neuronal protection, and lymphocyte egress from secondary lymphoid tissues. Although an agonist often activates the S1PR1, the receptor exhibits… read more here.
Keywords: first sphingosine; activation mechanisms; sphingosine phosphate; activation ... See more keywords
Sphingosine‐1‐phosphate related signalling pathways manipulating virus replication
Sign Up to like & getrecommendations! Published in 2023 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.2415
Abstract: Viruses can create a unique cellular environment that facilitates replication and transmission. Sphingosine kinases (SphKs) produce sphingosine‐1‐phosphate (S1P), a bioactive sphingolipid molecule that performs both physiological and pathological effects primarily by activating a subgroup of… read more here.
Keywords: replication; sphingosine; signalling pathways; virus ... See more keywords
Measuring Sphingosine-1-Phosphate/Protein Interactions with the Kinetic Exclusion Assay.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2017_5
Abstract: By directly detecting the ligand-free binding sites in a sample, the kinetic exclusion assay (KinExA®) provides a compelling alternative to SPR-based techniques for determining equilibrium dissociation constants of protein-ligand interactions. It is especially useful for… read more here.
Keywords: protein; kinetic exclusion; measuring sphingosine; sphingosine phosphate ... See more keywords
Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves’ orbitopathy
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation Research"
DOI: 10.1007/s00011-017-1037-3
Abstract: ObjectiveGraves’ orbitopathy (GO) is initiated by excessive amount of various inflammatory mediators produced by orbital fibroblasts. This study aimed to assess the crucial role of sphingosine-1-phosphate (S1P) in the inflammatory process of GO.MethodsOrbital adipose/connective tissue… read more here.
Keywords: s1p; sphingosine phosphate; inflammatory process; orbital fibroblasts ... See more keywords
Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Improve Mouse Status in Septic Peritonitis
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04414-2
Abstract: We examined the efficacy of embryoid bodies from 6-day induced pluripotent stem cells an in vivo sepsis model. Injection of embryoid bodies to septic mice improved the condition of their lungs and significantly increased their… read more here.
Keywords: sphingosine phosphate; pluripotent stem; embryoid bodies; induced pluripotent ... See more keywords
Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "CNS Drugs"
DOI: 10.1007/s40263-021-00798-w
Abstract: Fingolimod (Gilenya) received regulatory approval from the US FDA in 2010 as the first-in-class sphingosine 1-phosphate (S1P) receptor (S1PR) modulator and was the first oral disease-modifying therapy (DMT) used for the treatment of the relapsing… read more here.
Keywords: treatment; sphingosine phosphate; multiple sclerosis; receptor ... See more keywords