SPHK1‐induced autophagy in peritoneal mesothelial cell enhances gastric cancer peritoneal dissemination
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2041
Abstract: Gastric cancer peritoneal dissemination (GCPD) has been recognized as the most common form of metastasis in advanced gastric cancer (GC), and the survival is pessimistic. The injury of mesothelial cells plays an important role in… read more here.
Keywords: cancer peritoneal; gcpd; gastric cancer; sphk1 ... See more keywords
Up‐regulation and tumor‐promoting role of SPHK1 were attenuated by miR‐330‐3p in gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1934
Abstract: We intended to clarify the role of sphingosine kinase 1 (SPHK1) in gastric cancer (GC) using both in vitro and in vivo assays. The study was designed to identify novel therapeutic targets for GC treatment.… read more here.
Keywords: mir 330; gastric cancer; sphk1; expression ... See more keywords
Translocation and activation of sphingosine kinase 1 by ceramide‐1‐phosphate
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27818
Abstract: Sphingosine kinases (SphKs) and ceramide kinase (CerK) phosphorylate sphingosine to sphingosine‐1‐phosphate (S1P) and ceramide to ceramide‐1‐phosphate (C1P), respectively. S1P and C1P are bioactive lipids that regulate cell fate/function and human health/diseases. The translocation and activity… read more here.
Keywords: sphk1; ceramide; c1p; translocation ... See more keywords
SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1291479
Abstract: ABSTRACT SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, the mechanism by which SPHK1 signaling promotes… read more here.
Keywords: cdh1; degradation; sphk1; lysosomal degradation ... See more keywords
Lnc-HZ14 promotes LLPS-mediated SPHK1 aggrephagy degradation to suppress trophoblast cell proliferation in unexplained recurrent miscarriage.
Sign Up to like & getrecommendations! Published in 2025 at "Autophagy"
DOI: 10.1080/15548627.2025.2574963
Abstract: ABSTRACT High incidence of recurrent miscarriage (RM, recurrent abnormal early embryo loss) largely limits global human reproduction. However, it is unclear how the pathogenesis greatly restricts its effective clinical treatment. In our previous studies, we… read more here.
Keywords: proliferation; sphk1; lnc hz14; miscarriage ... See more keywords
Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model
Sign Up to like & getrecommendations! Published in 2018 at "Carcinogenesis"
DOI: 10.1093/carcin/bgx097
Abstract: Aberrant sphingolipid metabolism has been reported to promote breast cancer progression. Sphingosine kinase 1 (SphK1) is a key metabolic enzyme for the formation of pro-survival S1P from pro-apoptotic ceramide. The role of SphK1 in breast… read more here.
Keywords: breast; sphk1; positive breast; breast cancer ... See more keywords
Role of Sphingosine Kinase 1 in the Pathogenesis of Idiopathic Pulmonary Fibrosis: Identification of Novel Transcription Factors as Potential Therapeutic Targets by in silico Analysis
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5715018
Abstract: Introduction: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with no definitive treatment. However, a bioactive lipid mediator, sphingosine-1-phosphate (S1P) has been identified to have a role in the pathogenesis of IPF. S1P is… read more here.
Keywords: physiology; sphk1; silico analysis; fibrosis ... See more keywords
Sphingosine kinase 1 promotes arterial hypermuscularization with elastin deficiency
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.0129
Abstract: Introduction: Elastin is the major component of elastic lamellae that alternate with smooth muscle cells (SMCs) to form lamellar units in arteries. In humans, heterozygous loss-of-function mutations in the elastin gene ELN cause supravalvular aortic… read more here.
Keywords: physiology; elastin; sphingosine kinase; sphk1 ... See more keywords
The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Emergency Medicine International"
DOI: 10.1155/2022/6716143
Abstract: The aim of the study is to investigate the expression of sphingosine kinase 1 (SPHK1) and vascular endothelial growth factor (VEGF) in patients with endometrial carcinoma and its clinical significance. The tissues of 86 cases… read more here.
Keywords: patients endometrial; sphingosine kinase; endometrial carcinoma; expression ... See more keywords
Abstract 4142656: The Lack of Sphingosine Kinase 1 in Smooth Muscle Cells Protects Mice Against Angiotensin II-Induced Hypertension
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4142656
Abstract: Introduction: The function of the cardiovascular system is regulated by sphingosine-1-phosphate (S1P) signaling. Vascular sphingosine kinase 1 (Sphk1), an S1P-producing enzyme, is upregulated in hypertension (HTN), and mice lacking Sphk1 globally exhibit alleviated AngII-induced HTN.… read more here.
Keywords: mice; smooth muscle; sphingosine kinase; sphk1 ... See more keywords
Discovery of an SphK1 inhibitor: A hybrid approach involving a receptor–ligand-complex-based pharmacophore and docking-based virtual screening
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Research"
DOI: 10.1177/17475198221089222
Abstract: Sphingosine kinase is a lipid kinase that catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate. Sphingosine-1-phosphate is a bioactive lipid that regulates biological processes. The overexpression of sphingosine kinases is related to a variety of pathophysiological… read more here.
Keywords: sphingosine; sphk1 inhibitor; discovery sphk1; sphk1 ... See more keywords