Discovery of an SphK1 inhibitor: A hybrid approach involving a receptor–ligand-complex-based pharmacophore and docking-based virtual screening
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DOI: 10.1177/17475198221089222
Abstract: Sphingosine kinase is a lipid kinase that catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate. Sphingosine-1-phosphate is a bioactive lipid that regulates biological processes. The overexpression of sphingosine kinases is related to a variety of pathophysiological… read more here.
Keywords: sphingosine; sphk1 inhibitor; discovery sphk1; sphk1 ... See more keywords