PO-262 Differential expression of Sphingosine-1-Phosphate metabolising enzymes in oral squamous cell carcinoma
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DOI: 10.1136/esmoopen-2018-eacr25.294
Abstract: Introduction Sphingosine-1-phosphate (S1P), a potent signalling lipid. It mediates its actions by binding to a family of G-protein coupled receptors (GPCRs), known as S1P receptors. It has been implicated in the several processes integral to… read more here.
Keywords: sphk1 sphk2; metabolising enzymes; sphingosine phosphate; expression ... See more keywords
Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments.
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DOI: 10.2174/1381612825666190404115424
Abstract: BACKGROUND Sphingosine kinases (SphKs) catalyze the phosphorylation of sphingosine to form the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). S1P is an important lipid mediator with a wide range of biological functions; it is also involved in… read more here.
Keywords: sphk1 sphk2; design sphingosine; inhibitors challenges; sphingosine ... See more keywords