Inhibition of SphK2 Stimulated Hepatic Gluconeogenesis Associated with Dephosphorylation and Deacetylation of STAT3.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2018.11.001
Abstract: BACKGROUND Sphingosine kinase (SphK) is considered as a potential target for developing novel therapeutics of cancer and other diseases including diabetes. As the major SphK isoform in the liver, much less is known the role… read more here.
Keywords: inhibition sphk2; stat3; expression; sphk2 ... See more keywords
METTL3-mediated m6A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2
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DOI: 10.1038/s41388-021-01753-1
Abstract: N6-methyladenosine (m6A) RNA methylation is profoundly involved in epigenetic regulation, especially for carcinogenesis and tumor progression. Mounting evidence suggests that methyltransferase METTL3 regulates malignant behaviors of gastric cancer (GC). However, the clinical significance and biological… read more here.
Keywords: methylation; gastric cancer; mettl3; sphk2 ... See more keywords
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2007856117
Abstract: Significance Hepatic insulin resistance is a chief pathogenic determinant in the development of type 2 diabetes, which is often associated with abnormal hepatic lipid regulation. Sphingolipids are a class of essential lipids in the liver,… read more here.
Keywords: insulin; hepatic insulin; glucose homeostasis; sphk2 ... See more keywords
Abstract 1388: SphK2/S1P axis regulates hypoxia-mediated HIF-α synthesis in breast cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1388
Abstract: The hypoxia-inducible transcription factors (HIF)-1α and -2α play a critical role in cellular response to hypoxia in solid tumors. Elevated HIF-α expression correlates with poor patient survival in a large number of cancers including breast… read more here.
Keywords: hif; breast; breast cancer; sphk2 ... See more keywords
MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2.
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DOI: 10.3727/096504018x15151495109394
Abstract: Recent studies have revealed abnormal expression of miRNAs in various tumors. Although microRNA-338-3p (miR-338-3p) plays an important role in many types of tumors, its influence on liver cancer (LC) is unknown. In this study, we… read more here.
Keywords: targeting sphk2; microrna 338; sphk2; mir 338 ... See more keywords