Identification of porcine epidemic diarrhea virus variant with a large spike gene deletion from a clinical swine sample in the United States
Sign Up to like & getrecommendations! Published in 2018 at "Virus Genes"
DOI: 10.1007/s11262-018-1542-7
Abstract: Two genetically different porcine epidemic diarrhea virus (PEDV) strains have been identified in the USA: US prototype (also called non-S INDEL) and S INDEL PEDVs. In February 2017, a PEDV variant (USA/OK10240-8/2017) was identified in… read more here.
Keywords: porcine epidemic; epidemic diarrhea; deletion; spike gene ... See more keywords
A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation
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DOI: 10.1016/j.cell.2021.07.007
Abstract: The COVID-19 pandemic underscores the need to understand better animal-to-human transmission of coronaviruses and adaptive evolution within new hosts. We scanned over 182,000 SARS-CoV-2 genomes for selective sweep signatures and found a distinct footprint of… read more here.
Keywords: gene driven; selective sweep; spike gene; sars cov ... See more keywords
Spike gene variability in porcine epidemic diarrhea virus as a determinant for virulence
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DOI: 10.1128/jvi.02165-24
Abstract: ABSTRACT Porcine epidemic diarrhea virus (PEDV) is a pathogenic coronavirus that targets the swine intestinal tract, leading to acute diarrhea and high mortality in neonatal piglets. PEDV is categorized into different genotypes based on genetic… read more here.
Keywords: spike protein; diarrhea; spike gene; virulence ... See more keywords
Targeted detection and molecular epidemiology of turkey coronavirus spike gene variants in turkeys and chickens
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Veterinary Diagnostic Investigation"
DOI: 10.1177/10406387221128610
Abstract: Turkey coronavirus (TCoV) is a member of the Avian coronavirus species with infectious bronchitis virus (IBV), which is considered to be the source of TCoV. These 2 viruses are highly similar in all regions of… read more here.
Keywords: turkey; spike gene; coronavirus; molecular epidemiology ... See more keywords
Detection of feline coronavirus spike gene mutations as a tool to diagnose feline infectious peritonitis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x15623824
Abstract: Objectives Feline infectious peritonitis (FIP) is an important cause of death in the cat population worldwide. The ante-mortem diagnosis of FIP in clinical cases is still challenging. In cats without effusion, a definitive diagnosis can… read more here.
Keywords: infectious peritonitis; feline; feline infectious; spike gene ... See more keywords
Genomic surveillance of SARS-CoV-2 Spike gene by sanger sequencing
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DOI: 10.1371/journal.pone.0262170
Abstract: The SARS-CoV-2 responsible for the ongoing COVID pandemic reveals particular evolutionary dynamics and an extensive polymorphism, mainly in Spike gene. Monitoring the S gene mutations is crucial for successful controlling measures and detecting variants that… read more here.
Keywords: spike gene; genomic surveillance; gene; surveillance sars ... See more keywords
HiSpike Method for High-Throughput Cost Effective Sequencing of the SARS-CoV-2 Spike Gene
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.798130
Abstract: The changing nature of the SARS-CoV-2 pandemic poses unprecedented challenges to the world's health systems. Emerging spike gene variants jeopardize global efforts to produce immunity and reduce morbidity and mortality. These challenges require effective real-time… read more here.
Keywords: cost; spike gene; high throughput; gene ... See more keywords
Isolation and Identification of a Rare Spike Gene Double-Deletion SARS-CoV-2 Variant From the Patient With High Cycle Threshold Value
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.822633
Abstract: Coronavirus disease 2019 (COVID-19) is an emerging life-threatening pulmonary disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, Hubei Province, China, in December 2019. COVID-19 develops after close… read more here.
Keywords: double deletion; sars cov; isolation; spike gene ... See more keywords
Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies
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DOI: 10.3390/v14020226
Abstract: We explored the molecular evolution of the spike gene after the administration of anti-spike monoclonal antibodies in patients with mild or moderate forms of COVID-19. Four out of the 13 patients acquired a mutation during… read more here.
Keywords: moderate forms; spike gene; forms covid; monoclonal antibodies ... See more keywords
Fecal Feline Coronavirus RNA Shedding and Spike Gene Mutations in Cats with Feline Infectious Peritonitis Treated with GS-441524
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DOI: 10.3390/v14051069
Abstract: As previously demonstrated by our research group, the oral multicomponent drug Xraphconn® containing GS-441524 was effective at curing otherwise fatal feline infectious peritonitis (FIP) in 18 feline coronavirus (FCoV)-infected cats. The aims of the current… read more here.
Keywords: gene mutations; spike gene; rna; rna shedding ... See more keywords