Comprehensive role of SARS‐CoV‐2 spike glycoprotein in regulating host signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27820
Abstract: Since the outbreak of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, global public health and the economy have suffered unprecedented damage. Based on the increasing related literature, the… read more here.
Keywords: spike glycoprotein; host signaling; sars cov; role ... See more keywords
CLEC5A expression can be triggered by spike glycoprotein and may be a potential target for COVID‐19 therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28427
Abstract: The immune response is crucial for coronavirus disease 19 (COVID‐19) progression, with the participation of proinflammatory cells and cytokines, inducing lung injury and loss of respiratory function. CLEC5A expression on monocytes can be triggered by… read more here.
Keywords: spike glycoprotein; clec5a expression; triggered spike; expression ... See more keywords
Computer simulations on oxidative stress-induced reactions in SARS-CoV-2 spike glycoprotein: a multi-scale approach
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Diversity"
DOI: 10.1007/s11030-021-10373-6
Abstract: Abstract Oxidative stress, which occurs when an organism is exposed to an adverse stimulus that results in a misbalance of antioxidant and pro-oxidants species, is the common denominator of diseases considered as a risk factor… read more here.
Keywords: sars cov; stress; oxidative stress; cov spike ... See more keywords
The skin as a critical window in unveiling the pathophysiologic principles of COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Clinics in Dermatology"
DOI: 10.1016/j.clindermatol.2021.07.001
Abstract: The severe acute respiratory distress syndrome-associated coronavirus-2 (SARS-CoV-2), the etiologic agent of Coronavirus disease 2019 (COVID-19), is a single-stranded RNA virus whose sequence is known. COVID-19 is associated with a heterogeneous clinical phenotype ranging from… read more here.
Keywords: severe critical; covid; pathophysiologic principles; spike glycoprotein ... See more keywords
The human pandemic coronaviruses on the show: The spike glycoprotein as the main actor in the coronaviruses play
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Biological Macromolecules"
DOI: 10.1016/j.ijbiomac.2021.02.203
Abstract: Three coronaviruses (CoVs) have threatened the world population by causing outbreaks in the last two decades. In late 2019, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged and caused the coronaviruses to disease 2019 (COVID-19),… read more here.
Keywords: pandemic coronaviruses; coronaviruses show; human pandemic; spike glycoprotein ... See more keywords
A multiple peptides vaccine against COVID-19 designed from the nucleocapsid phosphoprotein (N) and Spike Glycoprotein (S) via the immunoinformatics approach
Sign Up to like & getrecommendations! Published in 2020 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2020.100476
Abstract: Due to the current Coronavirus (COVID-19) pandemic, the rapid discovery of a safe and effective vaccine is an essential issue. Consequently, this study aims to predict a potential COVID-19 peptide-based vaccine utilizing the Nucleocapsid phosphoprotein… read more here.
Keywords: nucleocapsid phosphoprotein; glycoprotein via; hla; covid ... See more keywords
A vaccine built from potential immunogenic pieces derived from the SARS-CoV-2 spike glycoprotein: A computational approximation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunological Methods"
DOI: 10.1016/j.jim.2022.113216
Abstract: Coronavirus Disease 2019 (COVID-19) represents a new global threat demanding a multidisciplinary effort to fight its etiological agent—severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this regard, immunoinformatics may aid to predict prominent immunogenic regions… read more here.
Keywords: multi epitope; sars cov; epitope vaccine; vaccine built ... See more keywords
Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: A computational biology approach
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DOI: 10.1016/j.meegid.2020.104389
Abstract: Abstract The newly identified SARS-CoV-2 has now been reported from around 185 countries with more than a million confirmed human cases including more than 120,000 deaths. The genomes of SARS-COV-2 strains isolated from different parts… read more here.
Keywords: spike protein; biology; spike glycoprotein; exploring genomic ... See more keywords
Immunoinformatics characterization of SARS-CoV-2 spike glycoprotein for prioritization of epitope based multivalent peptide vaccine
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.113612
Abstract: Abstract The COVID-19 pandemic caused by SARS-CoV-2 is a public health emergency of international concern and thus calling for the development of effective and safe therapeutics and prophylactics particularly a vaccine to protect against the… read more here.
Keywords: peptide vaccine; sars cov; spike glycoprotein; cov spike ... See more keywords
Screening of cryptogamic secondary metabolites as putative inhibitors of SARS-CoV-2 main protease and ribosomal binding domain of spike glycoprotein by molecular docking and molecular dynamics approaches
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130506
Abstract: The unprecedented quick spreading of newly emerged SARS-CoV-2, the virus responsible for causing COVID-19 has put the whole world in vast crisis. Several prophylactic interventions are being performed to discover the effective anti-COVID-19 agent. Thus,… read more here.
Keywords: cryptogamic secondary; binding domain; spike glycoprotein; sars cov ... See more keywords
Repurposing of FDA-Approved Toremifene to Treat COVID-19 by Blocking the Spike Glycoprotein and NSP14 of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.0c00397
Abstract: The global pandemic of Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to the death of more than 675,000 worldwide and over 150,000 in the United States alone.… read more here.
Keywords: nsp14 sars; covid; blocking spike; spike glycoprotein ... See more keywords