SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2022 at "Febs Letters"
DOI: 10.1002/1873-3468.14490
Abstract: SARS‐CoV‐2 spike (S) protein is crucial for virus invasion in COVID‐19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of… read more here.
Keywords: aggregation; cov spike; protein aggregation; spike protein ... See more keywords
Adaptation‐Proof SARS‐CoV‐2 Vaccine Design
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DOI: 10.1002/adfm.202206055
Abstract: Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) surface spike glycoprotein—a major antibody target—is critical for virus entry via engagement of human angiotensin‐converting enzyme 2 (ACE2) receptor. Despite successes with existing vaccines and therapies that… read more here.
Keywords: vaccine design; epitope scaffolds; sars cov; spike protein ... See more keywords
Molecular dynamics studies reveal structural and functional features of the SARS‐CoV‐2 spike protein
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DOI: 10.1002/bies.202200060
Abstract: The SARS‐CoV‐2 virus is responsible for the COVID‐19 pandemic the world experience since 2019. The protein responsible for the first steps of cell invasion, the spike protein, has probably received the most attention in light… read more here.
Keywords: molecular dynamics; dynamics studies; studies reveal; spike protein ... See more keywords
The Role of Spike Protein Mutations in the Infectious Power of SARS‐COV‐2 Variants: A Molecular Interaction Perspective
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DOI: 10.1002/cbic.202100393
Abstract: Abstract Specific S477N, N501Y, K417N, K417T, E484K mutations in the receptor binding domain (RBD) of the spike protein in the wild type SARS‐COV‐2 virus have resulted, among others, in the following variants: B.1.160 (20A or… read more here.
Keywords: first reported; role spike; sars cov; spike protein ... See more keywords
Charge Matters: Mutations in Omicron Variant Favor Binding to Cells
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DOI: 10.1002/cbic.202100681
Abstract: Evidence is strengthening to suggest that the novel SARS‐CoV‐2 mutant Omicron, with its more than 60 mutations, will spread and dominate worldwide. Although the mutations in the spike protein are known, the molecular basis for… read more here.
Keywords: omicron variant; mutations omicron; charge; charge matters ... See more keywords
Pineapple Lectin AcmJRL Binds SARS‐CoV‐2 Spike Protein in a Carbohydrate‐Dependent Fashion
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DOI: 10.1002/cbic.202200463
Abstract: The highly glycosylated spike protein of SARS‐CoV‐2 is essential for infection and constitutes a prime target for antiviral agents and vaccines. The pineapple‐derived jacalin‐related lectin AcmJRL is present in the medication bromelain in significant quantities… read more here.
Keywords: cov spike; acmjrl binds; lectin acmjrl; spike protein ... See more keywords
Probing structural basis for enhanced binding of SARS‐CoV‐2 P.1 variant spike protein with the human ACE2 receptor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30276
Abstract: The initial step of infection by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) involves the binding of receptor binding domain (RBD) of the spike protein to the angiotensin converting enzyme 2 (ACE2) receptor. Each successive… read more here.
Keywords: ace2 receptor; sars cov; receptor; spike protein ... See more keywords
All‐atom simulations of the trimeric spike protein of SARS‐CoV‐2 in aqueous medium: Nature of interactions, conformational stability and free energy diagrams for conformational transition of the protein
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DOI: 10.1002/jcc.27108
Abstract: The spike protein of SARS‐CoV‐2 exists in two major conformational states, namely the ‘open’ and ‘closed’ states which are also known as the ‘up’ and ‘down’ states, respectively. In its open state, the receptor binding… read more here.
Keywords: state; chain; free energy; spike protein ... See more keywords
Inclusion of MERS‐spike protein ELISA in algorithm to determine serologic evidence of MERS‐CoV infection
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DOI: 10.1002/jmv.24948
Abstract: The Centers for Disease Control and Prevention (CDC) algorithm for detecting presence of serum antibodies against Middle East Respiratory Syndrome coronavirus (MERS‐CoV) in subjects with potential infections with the virus has included screening by indirect… read more here.
Keywords: evidence; elisa; spike protein; inclusion mers ... See more keywords
N‐terminal domain of SARS CoV‐2 spike protein mutation associated reduction in effectivity of neutralizing antibody with vaccinated individuals
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DOI: 10.1002/jmv.27181
Abstract: Dear Editor The spike (S) protein is a homotrimer on the SARS‐CoV‐2 surface which targets the angiotensin‐converting enzyme‐2 in humans (ACE2). The Spike (S) coronavirus 2 (SARS‐CoV‐2) protein is a major driving force for viral… read more here.
Keywords: protein; terminal domain; cov spike; spike protein ... See more keywords
Emerging SARS-CoV-2 variants can potentially break set epidemiological barriers in COVID-19.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27467
Abstract: Young age, female sex, absence of comorbidities, and prior infection or vaccination are known epidemiological barriers for contracting the new infection and/or increased disease severity. Demographic trends from the recent COVID-19 waves, which are believed… read more here.
Keywords: epidemiological barriers; cov variants; spike protein; host cell ... See more keywords