SARS-CoV-2 vaccines: Lights and shadows
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Internal Medicine"
DOI: 10.1016/j.ejim.2021.04.019
Abstract: Vaccines to prevent acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection elicit an immune neutralizing response. Some concerns have been raised regarding the safety of SARS-CoV-2 vaccines, largely based on case-reports of serious thromboembolic events after… read more here.
Keywords: vaccines lights; spike proteins; response; lights shadows ... See more keywords
Differentiation of immortalized human multi-lineage progenitor to alveolar type 2-like cells: angiotensin-converting enzyme 2 expression and binding of severe acute respiratory syndrome coronavirus 2 spike and spike 1 proteins
Sign Up to like & getrecommendations! Published in 2021 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2021.07.017
Abstract: Along with the nasal epithelium, the lung epithelium is a portal of entry for sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and many other respiratory viruses. In the case of SARS-CoV-2, the virus surface spike… read more here.
Keywords: spike proteins; alveolar type; like cells; spike ... See more keywords
Concanavalin A targeting N-linked glycans in spike proteins influence viral interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/d0dt02932g
Abstract: Lectins, which exhibit viral-interaction abilities, have garnered attention in the current pandemic era as potential neutralizing agents and vaccine candidates. Viral invasion through envelope proteins is modulated by N-linked glycosylation in the spike (S) protein.… read more here.
Keywords: spike proteins; linked glycans; concanavalin targeting; proteins influence ... See more keywords
Computational ab initio interaction analyses between neutralizing antibody and SARS-CoV-2 variant spike proteins using the fragment molecular orbital method
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1246/bcsj.20210104
Abstract: The interaction energies between the receptor-binding domain of SARS-CoV-2 spike proteins and neutralizing antibody CC12.1 Fab were calculated using the fragment molecular orbital method. South Afr... read more here.
Keywords: using fragment; molecular orbital; spike proteins; neutralizing antibody ... See more keywords
Antibody accessibility determines location of spike surface mutations in SARS-CoV-2 variants
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1010822
Abstract: The steady emergence of SARS-CoV-2 variants gives us a real-time view of the interplay between viral evolution and the host immune defense. The spike protein of SARS-CoV-2 is the primary target of antibodies. Here, we… read more here.
Keywords: cov variants; antibody accessibility; sars cov; spike proteins ... See more keywords
Analysis of SARS-CoV-2 Spike Protein Variants with Recombinant Reporter Viruses Created from a Bacmid System
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098156
Abstract: SARS-CoV-2, the causative agent of COVID-19, has spread around the world with more than 700 million cases and 6.8 million deaths. Various variants of concern (VoC) have emerged due to mutations and recombination and concurrent… read more here.
Keywords: reporter; spike; spike proteins; spike protein ... See more keywords