SQNN: a spike-wave index quantification neural network with a pre-labeling algorithm for epileptiform activity identification and quantification in children
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/ac542e
Abstract: Objective. Electrical status epilepticus during slow sleep (ESES) is a phenomenon identified by strong activation of epileptiform activity in the electroencephalogram (EEG) during sleep. For children disturbed by ESES, spike-wave index (SWI) is defined to… read more here.
Keywords: swi; quantification; epileptiform activity; spike wave ... See more keywords
AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac037
Abstract: Abstract Metabolism regulates neuronal activity and modulates the occurrence of epileptic seizures. Here, using two rodent models of absence epilepsy, we show that hypoglycaemia increases the occurrence of spike-wave seizures. We then show that selectively… read more here.
Keywords: protein kinase; amp activated; activated protein; wave seizures ... See more keywords
Metyrapone abolishes Spike-Wave Discharge seizures in GAERS by reducing stress hormones.
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17584
Abstract: OBJECTIVE Stress is one of the most commonly reported triggers for seizures in patients with epilepsy, although the mechanisms which mediate this effect are not established. The clinical evidence supporting this is derived from patient's… read more here.
Keywords: stress; spike wave; stress hormones; seizures gaers ... See more keywords
Spike-Wave Discharges in Sprague Dawley Rats Reflect Precise Intra- and Inter-Hemispheric Synchronization of Somatosensory Cortex.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00303.2022
Abstract: Spike-wave discharges (SWDs) are among the most prominent electrical signals recordable from the rat cerebrum. Increased by inbreeding, SWDs have served as an animal model of human genetic absence seizures. Yet, SWDs are ubiquitous in… read more here.
Keywords: somatosensory; spike wave; cortex; somatosensory cortex ... See more keywords
Enhanced interlaminar excitation or reduced superficial layer inhibition in neocortex generates different spike-and-wave-like electrographic events in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurophysiology"
DOI: 10.1152/jn.00516.2017
Abstract: Acute in vitro models have revealed a great deal of information about mechanisms underlying many types of epileptiform activity. However, few examples exist that shed light on spike-and-wave (SpW) patterns of pathological activity. SpW are… read more here.
Keywords: enhanced interlaminar; pathology; superficial layer; vitro ... See more keywords
Surgically Remediable Secondary Network Epileptic Encephalopathies With Continuous Spike Wave in Sleep: Lesions May Not Be Visible on Brain Magnetic Resonance Imaging (MRI)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Child Neurology"
DOI: 10.1177/08830738221129919
Abstract: Background Continuous spike wave in sleep (CSWS) is an electroencephalogram (EEG) pattern associated with developmental and epileptic encephalopathy with spike-and-wave activation in sleep (DEE-SWAS). This etiologically heterogeneous syndrome may occur because of genetic factors and… read more here.
Keywords: magnetic resonance; brain magnetic; spike wave; brain ... See more keywords
European experience of steroid therapy in children with developmental and epileptic encephalopathy with spike wave activation in sleep ((D)EE-SWAS)
Sign Up to like & getrecommendations! Published in 2025 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-025-03725-0
Abstract: Developmental and epileptic encephalopathy with spike wave activation in sleep (DEE-SWAS) and epileptic encephalopathy with spike wave activation in sleep (EE-SWAS) are rare but well-known childhood epileptic disorders. Steroids are one of the first line… read more here.
Keywords: epileptic encephalopathy; treatment; therapy; swas ... See more keywords
Cortical Tonic Inhibition Gates the Expression of Spike-and-Wave Discharges Associated with Absence Epilepsy.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of integrative neuroscience"
DOI: 10.31083/j.jin2301024
Abstract: OBJECTIVE Absence seizures result from aberrant thalamocortical processing that confers synchronous, bilateral spike-and-wave discharges (SWDs) and behavioral arrest. Previous work has demonstrated that SWDs can result from enhanced thalamic tonic inhibition, consistent with the mechanism… read more here.
Keywords: inhibition; cortical tonic; tonic inhibition; spike wave ... See more keywords
Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.766566
Abstract: Wistar Albino Glaxo Rijswijk (WAG/Rij) rats are widely used in basic and pre-clinical studies as a valid genetic model of absence epilepsy. Adult WAG/Rij rats exhibit generalized 8–10-Hz spike-wave discharges (SWDs) in the electroencephalogram. SWDs… read more here.
Keywords: epilepsy wag; wag rij; sleep; wave epilepsy ... See more keywords
Closed-Loop Acoustic Stimulation During Sleep in Children With Epilepsy: A Hypothesis-Driven Novel Approach to Interact With Spike-Wave Activity and Pilot Data Assessing Feasibility
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Human Neuroscience"
DOI: 10.3389/fnhum.2019.00166
Abstract: Slow waves, the electroencephalographic (EEG) hallmark of deep sleep, can be systematically manipulated by acoustic stimulation: stimulation time-locked to the down phase of slow waves reduces, whereas stimulation time-locked to the up phase increases slow… read more here.
Keywords: stimulation; wave activity; acoustic stimulation; spike wave ... See more keywords
Alpha2 Adrenergic Modulation of Spike-Wave Epilepsy: Experimental Study of Pro-Epileptic and Sedative Effects of Dexmedetomidine
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119445
Abstract: In the present report, we evaluated adrenergic mechanisms of generalized spike-wave epileptic discharges (SWDs), which are the encephalographic hallmarks of idiopathic generalized epilepsies. SWDs link to a hyper-synchronization in the thalamocortical neuronal activity. We unclosed… read more here.
Keywords: wave epilepsy; alpha2 adrenergic; spike wave; dex ... See more keywords