Anatomical changes in descending serotonergic projections from the rostral ventromedial medulla to the spinal dorsal horn following repetitive neonatal painful procedures
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10185
Abstract: Excessive noxious stimulation during the critical neonatal period impacts the nociceptive network lasting into adulthood. As descending serotonergic projections from the rostral ventromedial medulla (RVM) to the spinal dorsal horn develop postnatally, this study aims… read more here.
Keywords: repetitive neonatal; descending serotonergic; spinal dorsal; dorsal horn ... See more keywords
Quercetin attenuates diabetic neuropathic pain by inhibiting mTOR/p70S6K pathway-mediated changes of synaptic morphology and synaptic protein levels in spinal dorsal horn of db/db mice.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173266
Abstract: Numerous studies indicate that the changes of synaptic morphology and synaptic protein levels in spinal dorsal horn neurons contributes to the development and maintenance of neuropathic pain. Quercetin, a bioflavonoid compound, has been shown to… read more here.
Keywords: spinal dorsal; dorsal horn; neuropathic pain; quercetin ... See more keywords
Effects of naftopidil on inhibitory transmission in substantia gelatinosa neurons of the rat spinal dorsal horn in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2017.07.030
Abstract: OBJECTIVE Naftopidil is used clinically for the treatment of voiding disorders in benign prostatic hyperplasia. Previous in vivo experiments in which naftopidil was applied intrathecally abolished rhythmic bladder contraction, suggesting that naftopidil might inhibit a… read more here.
Keywords: dorsal horn; substantia gelatinosa; spinal dorsal; dorsal ... See more keywords
Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.07.010
Abstract: Astrocytes are the most abundant glial cells in the central nervous system (CNS), including the spinal cord. Neuronal damage induces astrocytes to become reactive and contribute to various CNS pathologies. Recent studies have demonstrated that… read more here.
Keywords: itch; spinal dorsal; dorsal horn; itch conditions ... See more keywords
Astrocytes in the spinal dorsal horn and chronic itch
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.08.010
Abstract: Chronic itch is a hallmark symptom of inflammatory skin conditions, such as atopic dermatitis. Existing treatment for chronic itch is largely ineffective. Despite recent progress in our understanding of the neuronal basis for itch sensation… read more here.
Keywords: itch; spinal dorsal; dorsal horn; chronic itch ... See more keywords
Neuron-specific responses to acetylcholine within the spinal dorsal horn circuits of rodent and primate
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108755
Abstract: Excitatory and inhibitory neurotransmission within the spinal dorsal horn is tightly controlled to regulate transmission of nociceptive signals to the brain. One aspect of this control is modulation of neuronal activity through cholinergic signaling. Nociceptive… read more here.
Keywords: spinal dorsal; dorsal horn; specific responses; activity ... See more keywords
Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn
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DOI: 10.1038/s41598-018-25110-7
Abstract: The spinal dorsal horn (SDH) is comprised of distinct neuronal populations that process different somatosensory modalities. Somatostatin (SST)-expressing interneurons in the SDH have been implicated specifically in mediating mechanical pain. Identifying the transcriptomic profile of… read more here.
Keywords: transcriptional profiling; spinal dorsal; dorsal horn; somatostatin interneurons ... See more keywords
Differential expression of Na+/K+/Cl− cotransporter 1 in neurons and glial cells within the superficial spinal dorsal horn of rodents
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68638-3
Abstract: Although convincing experimental evidence indicates that Na+/K+/Cl− cotransporter 1 (NKCC1) is involved in spinal nociceptive information processing and in the generation of hyperalgesia and allodynia in chronic pain states, the cellular distribution of NKCC1 in… read more here.
Keywords: glial cells; dorsal horn; axon terminals; spinal dorsal ... See more keywords
The Novel Gabapentinoid Mirogabalin Prevents Upregulation of α 2 δ-1 Subunit of Voltage-Gated Calcium Channels in Spinal Dorsal Horn in a Rat Model of Spinal Nerve Ligation
Sign Up to like & getrecommendations! Published in 2022 at "Drug Research"
DOI: 10.1055/a-1941-8907
Abstract: Abstract Gabapentinoids are specific ligands for the α 2 δ-1 subunit of voltage-gated calcium channels. This class of drugs, including gabapentin and pregabalin, exert various pharmacological effects and are widely used for the treatment of… read more here.
Keywords: mirogabalin; spinal dorsal; nerve; model ... See more keywords
Stereological study on the number of synapses in the rat spinal dorsal horn with painful diabetic neuropathy induced by streptozotocin
Sign Up to like & getrecommendations! Published in 2017 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000762
Abstract: Our previous studies showed that direct injury to the sciatic nerve (chronic constriction injury or axotomy) is associated with a numerical increase in synaptic number in the rat spinal dorsal horn. The aim of this… read more here.
Keywords: spinal dorsal; dorsal horn; number; stz rats ... See more keywords
Oxaliplatin-loaded monomethoxy (polyethylene glycol)–poly(d, l-lactic-co-glycolic acid) nanoparticles induced neuropathic pain through the pro-inflammatory effect of microglia in the spinal dorsal horn mediated by Zic2/membrane adapter protein 12
Sign Up to like & getrecommendations! Published in 2020 at "Materials Express"
DOI: 10.1166/mex.2020.1771
Abstract: The aim of this study is to investigate the effect and mechanism of oxaliplatin (OX)-loaded monomethoxy (polyethylene glycol)–poly(d, l-lactic-co-glycolic acid) (mPEG–PLGA) nanoparticles on neuropathic pain induced by pro-inflammatory action of Zic2/membrane adaptor protein 12 (DAP12)… read more here.
Keywords: spinal dorsal; dorsal horn; induced neuropathic; zic2 ... See more keywords