Recombinant interleukin‐4 alleviates mechanical allodynia via injury‐induced interleukin‐4 receptor alpha in spinal microglia in a rat model of neuropathic pain
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DOI: 10.1002/glia.23340
Abstract: Glial cells play important roles in the development and maintenance of neuropathic pain. In particular, activated microglia in the spinal cord facilitate the hyper‐excitability of dorsal horn neurons after peripheral nerve injury via pro‐inflammatory molecules.… read more here.
Keywords: spinal microglia; injury induced; neuropathic pain; nerve injury ... See more keywords
Sex‐specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury
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DOI: 10.1002/glia.24133
Abstract: Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by activation in glial cells in various pain‐related regions within the central nervous system. Recent studies have suggested a sexually dimorphic role of… read more here.
Keywords: spinal microglia; sex; neuropathic pain; pain ... See more keywords
Liposome-encapsulated clodronate specifically depletes spinal microglia and reduces initial neuropathic pain.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.177
Abstract: Liposome-encapsulated clodronate (LEC) is a specific depletor of macrophages. Our study characterized the LEC depletory effects, given intrathecally, on spinal microglia and assessed its effects on initiation and maintenance of neuropathic pain. Measured by using… read more here.
Keywords: spinal microglia; encapsulated clodronate; neuropathic pain; liposome encapsulated ... See more keywords
A spinal microglia population involved in remitting and relapsing neuropathic pain.
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DOI: 10.1126/science.abf6805
Abstract: Neuropathic pain is often caused by injury and diseases that affect the somatosensory system. Although pain development has been well studied, pain recovery mechanisms remain largely unknown. Here, we found that CD11c-expressing spinal microglia appear… read more here.
Keywords: involved remitting; pain; spinal microglia; microglia population ... See more keywords
The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain.
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DOI: 10.1177/17448069221099360
Abstract: Prolongation of postsurgical pain caused by pre-operative stress is a clinically significant problem, although the mechanisms are not fully understood. Stress can promote the pro-inflammatory activation of microglia, and the transcription factor CCAAT/enhancer-binding protein (C/EBP)… read more here.
Keywords: spinal microglia; pain; pre operative; stress ... See more keywords
Optogenetic activation of spinal microglia triggers chronic pain in mice
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DOI: 10.1371/journal.pbio.3001154
Abstract: Spinal microglia are highly responsive to peripheral nerve injury and are known to be a key player in pain. However, there has not been direct evidence showing that selective microglial activation in vivo is sufficient… read more here.
Keywords: reachr; spinal microglia; activation; chronic pain ... See more keywords