Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2020.101894
Abstract: An accelerating basic science literature is providing key insights into the mechanisms by which spinal neuropeptide Y (NPY) inhibits chronic pain. A key target of pain inhibition is the Gi-coupled neuropeptide Y1 receptor (Y1). Y1… read more here.
Keywords: neuropeptide receptor; pain itch; spinal neuropeptide; chronic pain ... See more keywords
Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204515119
Abstract: Significance Neuropathic pain is a debilitating chronic pain condition that is poorly responsive to currently available analgesic drugs. A widespread clinical need remains for novel, safe, and efficacious nonopioid therapeutics for afflicted patients. Using a… read more here.
Keywords: neuropeptide receptor; receptor expressing; neuropathic pain; pain ... See more keywords