Spinal PKCĪ± inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons
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DOI: 10.1038/s41598-018-28512-9
Abstract: Upregulation of Ca2+-permeable AMPA receptors (CP-AMPARs) in dorsal horn (DH) neurons has been causally linked to persistent inflammatory pain. This upregulation, demonstrated for both synaptic and extrasynaptic AMPARs, depends on the protein kinase C alpha… read more here.
Keywords: spinal pkc; synapses primary; pkc inhibition; pain ... See more keywords