Modulation of excitatory synaptic transmissions by TRPV1 in the spinal trigeminal subnucleus caudalis neurons of neuropathic pain rats.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174625
Abstract: The present study examined contribution of the transient receptor potential vanilloid 1 channel (TRPV1) to the chronic orofacial pain. Bilateral partial nerve ligation (PNL) of the mental nerve, a branch of trigeminal nerve, was performed… read more here.
Keywords: pnl rats; sham rats; neuropathic pain; pnl ... See more keywords
Systemic administration of α-lipoic acid suppresses excitability of nociceptive wide-dynamic range neurons in rat spinal trigeminal nucleus caudalis
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Research"
DOI: 10.1016/j.neures.2018.06.003
Abstract: Although a modulatory role has been reported for α-lipoic acid (LA) on T-type Ca2+ channels in the nervous system, the acute effects of LA in vivo, particularly on nociceptive transmission in the trigeminal system, remain… read more here.
Keywords: wide dynamic; administration; trigeminal nucleus; dynamic range ... See more keywords
Dopamine receptor D2, but not D1, mediates descending dopaminergic pathway–produced analgesic effect in a trigeminal neuropathic pain mouse model
Sign Up to like & getrecommendations! Published in 2019 at "PAIN"
DOI: 10.1097/j.pain.0000000000001414
Abstract: Abstract Neuropathic pain represents a challenge to clinicians because it is resistant to commonly prescribed analgesics due to its largely unknown mechanisms. Here, we investigated a descending dopaminergic pathway–mediated modulation of trigeminal neuropathic pain. We… read more here.
Keywords: dopaminergic pathway; descending dopaminergic; neuropathic pain; spinal trigeminal ... See more keywords
Transient activation of spinal trigeminal neurons in a rat model of hypoxia-induced headache.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000002114
Abstract: The mechanisms underlying headaches attributed to hypoxia are poorly known. The activation of spinal trigeminal neurons with meningeal afferent input is thought to be responsible for the generation of headaches.In the caudal spinal trigeminal nucleus… read more here.
Keywords: transient activation; trigeminal neurons; spinal trigeminal; activity ... See more keywords
A Viral Labelling Study of Spinal Trigeminal Nucleus Caudalis Projection Neurons Targeting the Parabrachial Nucleus
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.70028
Abstract: Projection neurons (PNs) in the Spinal Trigeminal Nucleus Caudalis (Sp5C) relay orofacial nociceptive information to higher brain regions such as the thalamus and the parabrachial nucleus (PBN). Our understanding of Sp5C PN organisation and function… read more here.
Keywords: spinal trigeminal; projection; nucleus caudalis; trigeminal nucleus ... See more keywords
Deterministic Tractography of the Descending Tract of the Spinal Trigeminal Nerve Using Diffusion Tensor Imaging
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroimaging"
DOI: 10.1111/jon.12425
Abstract: Pain information from the face enters the pons via the trigeminal nerve before creating an anatomical “elbow” that turns caudally into the spinal trigeminal tract (SpTV). Visualization of the descending tract of the trigeminal nerve… read more here.
Keywords: descending tract; using diffusion; trigeminal nerve; nerve ... See more keywords
H3 Receptor Expression in the Spinal Trigeminal Nucleus Caudalis in a Rat Model of Allergic Rhinitis
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.544
Abstract: Background: Allergic rhinitis is one of the most frequently observed allergic diseases. Although antihistamine medication is an effective symptomatic treatment for this disease, it is not suffcient enough to improve quality of life, requiring an… read more here.
Keywords: spinal trigeminal; allergic rhinitis; physiology; model ... See more keywords
Hydrogen Sulfide Mediating both Excitatory and Inhibitory Effects in a Rat Model of Meningeal Nociception and Headache Generation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2017.00336
Abstract: Background/purpose Hydrogen sulfide (H2S) is a neuromodulator acting through nitroxyl (HNO) when it reacts with nitric oxide (NO). HNO activates transient receptor potential channels of the ankyrin type 1 (TRPA1) causing release of calcitonin gene-related… read more here.
Keywords: model meningeal; rat model; hydrogen sulfide; spinal trigeminal ... See more keywords