PCH-2TRIP13 regulates spindle checkpoint strength.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e20-05-0310
Abstract: Spindle checkpoint strength is dictated by the number of unattached kinetochores, cell volume and cell fate. We show that the conserved AAA-ATPase, PCH-2/TRIP13, which remodels the checkpoint effector Mad2 from an active conformation to an… read more here.
Keywords: media see; spindle checkpoint; see text; text media ... See more keywords
Meiotic cells escape prolonged spindle checkpoint activity through kinetochore silencing and slippage.
Sign Up to like & getrecommendations! Published in 2023 at "PLoS genetics"
DOI: 10.1371/journal.pgen.1010707
Abstract: To prevent chromosome mis-segregation, a surveillance mechanism known as the spindle checkpoint delays the cell cycle if kinetochores are not attached to spindle microtubules, allowing the cell additional time to correct improper attachments. During spindle… read more here.
Keywords: slippage; checkpoint activity; meiotic cells; checkpoint ... See more keywords