Regulators of spindle microtubules and their mechanisms: Living together matters
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1708
Abstract: Development and survival of all eukaryotic organisms depend on equal partitioning of their chromosomes between the two newly formed daughter cells during mitosis. The mitotic spindle performs the task of physically segregating the chromosomes through… read more here.
Keywords: microtubule; kinetochore microtubule; mechanisms living; microtubules mechanisms ... See more keywords
Central-spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-01-0074
Abstract: Spindle microtubules, whose dynamics vary over time and at different locations, cooperatively drive chromosome segregation. Measurements of microtubule dynamics and spindle ultrastructure can provide insight into the behaviors of microtubules, helping elucidate the mechanism of… read more here.
Keywords: central spindle; spindle microtubules; chromosome segregation; microtubules strongly ... See more keywords
SKAP interacts with Aurora B to guide end-on capture of spindle microtubules via phase separation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjab058
Abstract: Chromosome segregation in mitosis is orchestrated by the dynamic interactions between the kinetochore and spindle microtubules. Our recent studies show that mitotic motor CENP-E cooperates with SKAP and forms a link between kinetochore core MIS13… read more here.
Keywords: phase separation; end; skap; via phase ... See more keywords