Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
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DOI: 10.1016/j.rbmo.2017.01.013
Abstract: Mutations in mitochondrial DNA (mtDNA) are maternally inherited and can cause fatal or debilitating mitochondrial disorders. The severity of clinical symptoms is often associated with the level of mtDNA mutation load or degree of heteroplasmy.… read more here.
Keywords: mtdna mutation; spindle transfer; transfer;
First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2017.02.004
Abstract: In this issue, Zhang et al. (2017) report the birth of a healthy boy after mitochondrial replacement therapy (MRT) by spindle transfer to prevent transmission of mitochondrial disease from mother to child. The case was… read more here.
Keywords: replacement therapy; spindle transfer; first birth; mitochondrial replacement ... See more keywords