Protracted dendritic growth in the typically developing human amygdala and increased spine density in young ASD brains
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24332
Abstract: The amygdala is a medial temporal lobe structure implicated in social and emotional regulation. In typical development (TD), the amygdala continues to increase volumetrically throughout childhood and into adulthood, while other brain structures are stable… read more here.
Keywords: age; spine density; asd; amygdala ... See more keywords
Acute MPTP treatment decreases dendritic spine density of striatal medium spiny neurons via SNK‐SPAR pathway in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22249
Abstract: Parkinson's disease (PD) is a well‐known neurodegenerative disorder associated with a high risk in middle‐aged and elderly individuals, severely impacting the patient's quality of life. 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) is frequently used to establish PD in animals.… read more here.
Keywords: dendritic spine; mptp; density striatal; spine density ... See more keywords
Increased thin-spine density in frontal cortex pyramidal neurons in a genetic rat model of schizophrenia-relevant features
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.01.006
Abstract: The cellular mechanisms altered during brain wiring leading to cognitive disturbances in neurodevelopmental disorders remain unknown. We have previously reported altered cortical expression of neurodevelopmentally regulated synaptic markers in a genetic animal model of schizophrenia-relevant… read more here.
Keywords: model schizophrenia; spine density; schizophrenia relevant; density ... See more keywords
Repeated exposure to methiopropamine increases dendritic spine density in the rat nucleus accumbens core
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.104487
Abstract: Repeated exposure to classical psychomotor stimulants, like amphetamine (AMPH), produces locomotor sensitization and accompanied structural plasticity of dendritic spines in the nucleus accumbens (NAcc). Following our previous report that repeated administration of methiopropamine (MPA), a… read more here.
Keywords: exposure methiopropamine; repeated exposure; spine density; nucleus accumbens ... See more keywords
Decrease in neuronal spine density in the postpartum period in the amygdala and bed nucleus of the stria terminalis in rat
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.01.040
Abstract: In pregnancy and the postpartum period, many women have emotional instability and some suffer from depression. The ovarian steroid hormone milieu is markedly changed during these periods, and this hormonal change may be an important… read more here.
Keywords: spine density; postpartum period; density; bed nucleus ... See more keywords
The detrimental effects of APOE4 on risk for Alzheimer's disease may result from altered dendritic spine density, synaptic proteins, and estrogen receptor alpha
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2021.12.006
Abstract: Women carriers of APOE4, the greatest genetic risk factor for late-onset Alzheimer's disease (AD), are at highest risk of developing AD, yet factors underlying interactions between APOE4 and sex are not well characterized. Here, we… read more here.
Keywords: sex; risk; dendritic spine; spine density ... See more keywords
Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.01.026
Abstract: Isoprenoids and prenylated proteins regulate a variety of cellular functions, including neurite growth and synaptic plasticity. Importantly, they are implicated in the pathogenesis of several diseases, including Alzheimer's disease (AD). Recently, we have shown that… read more here.
Keywords: ggt; neuron specific; spine density; mice ... See more keywords
Pre-weaning paternal deprivation impairs social recognition and alters hippocampal neurogenesis and spine density in adult mandarin voles
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.09.006
Abstract: &NA; Disruption of the early social environment, such as maternal separation or early deprivation, can impair cognitive function, alter offspring neurogenesis and restrict dendritic architecture in the hippocampus. However, whether paternal deprivation during the pre‐weaning… read more here.
Keywords: neurogenesis spine; spine density; deprivation; paternal deprivation ... See more keywords
Effects of adolescent Bisphenol-A exposure on memory and spine density in ovariectomized female rats: Adolescence vs adulthood
Sign Up to like & getrecommendations! Published in 2019 at "Hormones and Behavior"
DOI: 10.1016/j.yhbeh.2018.11.004
Abstract: Abstract The endocrine disruptor, Bisphenol‐A (BPA), alters many behavioral and neural parameters in rodents. BPA administration to gonadally intact adolescent rats increases anxiety, impairs spatial memory, and decreases dendritic spine density when measured in adulthood.… read more here.
Keywords: bpa; spine density; density; memory ... See more keywords
Mild Traumatic Brain Injury Reduces Spine Density of Projection Neurons in the Medial Prefrontal Cortex and Impairs Extinction of Contextual Fear Memory.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurotrauma"
DOI: 10.1089/neu.2016.4898
Abstract: Epidemiology studies have found that a comorbidity exists between traumatic brain injury (TBI) and stress-related disorders. However, the anatomical and cellular bases for this association is poorly understood. An inability to extinguish the memory of… read more here.
Keywords: cortex; spine density; projection neurons; injury ... See more keywords
The HD-ZIP IV transcription factor Tril regulates fruit spine density through dose effects in cucumber.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of experimental botany"
DOI: 10.1093/jxb/eraa344
Abstract: Trichomes and fruit spines are important traits that directly affect the appearance quality and commercial value of cucumber. Tril (Trichome-less), an HD-Zip IV transcription factor, plays a crucial role in the initiation of trichomes and… read more here.
Keywords: spine density; fruit spine; tril; factor ... See more keywords