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   Articles with "spine density" as a keyword



Protracted dendritic growth in the typically developing human amygdala and increased spine density in young ASD brains

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recommendations! Published in 2018 at "Journal of Comparative Neurology"

DOI: 10.1002/cne.24332

Abstract: The amygdala is a medial temporal lobe structure implicated in social and emotional regulation. In typical development (TD), the amygdala continues to increase volumetrically throughout childhood and into adulthood, while other brain structures are stable… read more here.

Keywords: age; spine density; asd; amygdala ... See more keywords

Repopulated microglia after pharmacological depletion decrease dendritic spine density in adult mouse brain

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recommendations! Published in 2024 at "Glia"

DOI: 10.1002/glia.24541

Abstract: Microglia are innate immune cells in the brain and show exceptional heterogeneity. They are key players in brain physiological development regulating synaptic plasticity and shaping neuronal networks. In pathological disease states, microglia‐induced synaptic pruning mediates… read more here.

Keywords: depletion; microglia depletion; brain; spine density ... See more keywords

Acute MPTP treatment decreases dendritic spine density of striatal medium spiny neurons via SNK‐SPAR pathway in C57BL/6 mice

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recommendations! Published in 2022 at "Synapse"

DOI: 10.1002/syn.22249

Abstract: Parkinson's disease (PD) is a well‐known neurodegenerative disorder associated with a high risk in middle‐aged and elderly individuals, severely impacting the patient's quality of life. 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) is frequently used to establish PD in animals.… read more here.

Keywords: dendritic spine; mptp; density striatal; spine density ... See more keywords
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Increased thin-spine density in frontal cortex pyramidal neurons in a genetic rat model of schizophrenia-relevant features

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recommendations! Published in 2021 at "European Neuropsychopharmacology"

DOI: 10.1016/j.euroneuro.2021.01.006

Abstract: The cellular mechanisms altered during brain wiring leading to cognitive disturbances in neurodevelopmental disorders remain unknown. We have previously reported altered cortical expression of neurodevelopmentally regulated synaptic markers in a genetic animal model of schizophrenia-relevant… read more here.

Keywords: model schizophrenia; spine density; schizophrenia relevant; density ... See more keywords

Repeated exposure to methiopropamine increases dendritic spine density in the rat nucleus accumbens core

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recommendations! Published in 2019 at "Neurochemistry International"

DOI: 10.1016/j.neuint.2019.104487

Abstract: Repeated exposure to classical psychomotor stimulants, like amphetamine (AMPH), produces locomotor sensitization and accompanied structural plasticity of dendritic spines in the nucleus accumbens (NAcc). Following our previous report that repeated administration of methiopropamine (MPA), a… read more here.

Keywords: exposure methiopropamine; repeated exposure; spine density; nucleus accumbens ... See more keywords

Decrease in neuronal spine density in the postpartum period in the amygdala and bed nucleus of the stria terminalis in rat

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recommendations! Published in 2017 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2017.01.040

Abstract: In pregnancy and the postpartum period, many women have emotional instability and some suffer from depression. The ovarian steroid hormone milieu is markedly changed during these periods, and this hormonal change may be an important… read more here.

Keywords: spine density; postpartum period; density; bed nucleus ... See more keywords

The detrimental effects of APOE4 on risk for Alzheimer's disease may result from altered dendritic spine density, synaptic proteins, and estrogen receptor alpha

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recommendations! Published in 2022 at "Neurobiology of Aging"

DOI: 10.1016/j.neurobiolaging.2021.12.006

Abstract: Women carriers of APOE4, the greatest genetic risk factor for late-onset Alzheimer's disease (AD), are at highest risk of developing AD, yet factors underlying interactions between APOE4 and sex are not well characterized. Here, we… read more here.

Keywords: sex; risk; dendritic spine; spine density ... See more keywords

Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density

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recommendations! Published in 2018 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2018.01.026

Abstract: Isoprenoids and prenylated proteins regulate a variety of cellular functions, including neurite growth and synaptic plasticity. Importantly, they are implicated in the pathogenesis of several diseases, including Alzheimer's disease (AD). Recently, we have shown that… read more here.

Keywords: ggt; neuron specific; spine density; mice ... See more keywords

Pre-weaning paternal deprivation impairs social recognition and alters hippocampal neurogenesis and spine density in adult mandarin voles

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recommendations! Published in 2018 at "Neurobiology of Learning and Memory"

DOI: 10.1016/j.nlm.2018.09.006

Abstract: &NA; Disruption of the early social environment, such as maternal separation or early deprivation, can impair cognitive function, alter offspring neurogenesis and restrict dendritic architecture in the hippocampus. However, whether paternal deprivation during the pre‐weaning… read more here.

Keywords: neurogenesis spine; spine density; deprivation; paternal deprivation ... See more keywords

Effects of adolescent Bisphenol-A exposure on memory and spine density in ovariectomized female rats: Adolescence vs adulthood

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recommendations! Published in 2019 at "Hormones and Behavior"

DOI: 10.1016/j.yhbeh.2018.11.004

Abstract: Abstract The endocrine disruptor, Bisphenol‐A (BPA), alters many behavioral and neural parameters in rodents. BPA administration to gonadally intact adolescent rats increases anxiety, impairs spatial memory, and decreases dendritic spine density when measured in adulthood.… read more here.

Keywords: bpa; spine density; density; memory ... See more keywords

Effects of cholestasis and hyperammonemia on dendritic spine density and turnover in rat hippocampal neurons

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-80871-8

Abstract: Adults and children with cholestatic liver disease are at risk for type C hepatic encephalopathy (HE) and may present lifelong neurocognitive impairment. While the underlying cellular and molecular mechanisms are still incompletely understood, ammonium and… read more here.

Keywords: rat hippocampal; dendritic spine; spine density; spine ... See more keywords