Dendritic spine loss caused by AlCl3 is associated with inhibition of the Rac 1/cofilin signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental pollution"
DOI: 10.1016/j.envpol.2018.09.145
Abstract: Aluminum (Al) has neurotoxicity that can result in cognitive dysfunction. Hippocampal dendritic spine loss is a pathological characteristic of cognitive dysfunction. Our previous study reported that Al exposure caused dendritic spine loss in the hippocampus,… read more here.
Keywords: dendritic spine; spine loss; rac cofilin;
Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.09.052
Abstract: Summary Synaptic scaling is a key homeostatic plasticity mechanism and is thought to be involved in the regulation of cortical activity levels. Here we investigated the spatial scale of homeostatic changes in spine size following… read more here.
Keywords: synaptic scaling; dendritic branches; deprivation; spine loss ... See more keywords
Regulation of Cdc42 signaling by the dopamine D2 receptor in a mouse model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13588
Abstract: Substantial spine loss in striatal medium spiny neurons (MSNs) and abnormal behaviors are common features of Parkinson's disease (PD). The caudate putamen (CPu) mainly contains MSNs expressing dopamine D1 receptor (dMSNs) and dopamine D2 receptor… read more here.
Keywords: dopamine receptor; d2r; spine loss; cdc42 signaling ... See more keywords