Performance of SPINK1 and SPINK1-based diagnostic model in detection of hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24025
Abstract: OBJECTIVES To identify the SPINK1 or SPINK1-based model as a more reliable biomarker for the diagnosis of hepatocellular carcinoma (HCC). METHODS Serum samples and related laboratory parameters were collected from 540 subjects (119 healthy donors, 113 patients… read more here.
Keywords: spink1 based; sensitivity; model; specificity ... See more keywords
Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06860-4
Abstract: Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal cells in the tumour microenvironment (TME), inducing a senescence-associated secretory phenotype (SASP) characterized by chronic secretion of diverse soluble factors. Here we… read more here.
Keywords: stromal cells; resistance; cancer; tumour microenvironment ... See more keywords
Current Perspective in the Management of Hepatocellular Carcinoma: Time to Get Personal!
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Investigative Surgery"
DOI: 10.1080/08941939.2020.1747576
Abstract: The paper “High SPINK1 expression predicts poor prognosis and promotes cell proliferation and metastasis of hepatocellular carcinoma” evaluates the prognostic value and role of serine protease inhibitor Kazal type I (SPINK1) in the proliferation and… read more here.
Keywords: hepatocellular carcinoma; carcinoma; hcc; time ... See more keywords
Abstract 140: Clonal evaluation of ERG/SPINK1 status to determine disease progression using whole mount prostatectomy specimens
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-140
Abstract: Most primary prostate cancers are multifocal, marked by distinct tumor foci. Multiclonality is not routinely incorporated at clinical evaluation, however, marker status as a pathological parameter holds great potential for improving prognostic accuracy. Here, we… read more here.
Keywords: erg spink1; whole mount; spink1; status ... See more keywords
Serine Protease Inhibitor Kazal Type 1, A Potential Biomarker for the Early Detection, Targeting, and Prediction of Response to Immune Checkpoint Blockade Therapies in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.923031
Abstract: Background We aimed to characterize serine protease inhibitor Kazal type 1 (SPINK1) as a gene signature for the early diagnosis, molecular targeting, and prediction of immune checkpoint blockade (ICB) treatment response of hepatocellular carcinoma (HCC).… read more here.
Keywords: response; spink1; serine protease; hcc ... See more keywords
Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073468
Abstract: (1) The serine protease inhibitor Kazal type 1 (SPINK1) inhibits trypsin activity in zymogen granules of pancreatic acinar cells. Several mutations in the SPINK1 gene are associated with acute recurrent pancreatitis (ARP) and chronic pancreatitis… read more here.
Keywords: spink1; biophysical insights; cationic trypsin; human cationic ... See more keywords
SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker
Sign Up to like & getrecommendations! Published in 2018 at "BMB Reports"
DOI: 10.5483/bmbrep.2018.51.12.205
Abstract: Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration, and invasion. Mechanistically, we… read more here.
Keywords: lung adenocarcinoma; biomarker; growth; spink1 ... See more keywords