Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202412963
Abstract: Timing perception is a fundamental cognitive function that allows organisms to navigate their environment effectively, encompassing both prospective and retrospective timing. Despite significant advancements in understanding how the brain processes temporal information, the neural mechanisms… read more here.
Keywords: perception; timing perception; spiny neurons; medium spiny ... See more keywords
Enduring effects of juvenile social isolation on physiological properties of medium spiny neurons in nucleus accumbens
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05284-2
Abstract: RationaleJuvenile social isolation (SI) and neglect is associated with a wide range of psychiatric disorders. While dysfunction of the corticolimbic pathway is considered to link various abnormal behaviors in SI models of schizophrenia, the enduring… read more here.
Keywords: enduring effects; social isolation; spiny neurons; physiological properties ... See more keywords
Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.08.106
Abstract: Huntington's disease (HD) is a hereditary neurodegenerative disease caused by a polyglutamine expansion within the huntingtin (HTT) gene. One of the cellular functions that is dysregulated in HD is store-operated calcium entry (SOCE), a process… read more here.
Keywords: yac128 mice; huntington disease; spiny neurons; disease ... See more keywords
Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.03.010
Abstract: The mechanisms of dopamine dysregulation syndrome (DDS) in Parkinson's disease (PD) remain unclear, although it is known that the nucleus accumbens (NAc) plays a role in its development. Based on the hypothesis that DDS and… read more here.
Keywords: dendritic spine; spiny neurons; nucleus accumbens; medium spiny ... See more keywords
High ethanol sensitive glycine receptors regulate firing in D1 medium spiny neurons in the nucleus accumbens
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107773
Abstract: Inhibitory glycine receptors (GlyRs) are widely expressed in spinal cord and brain stem. They are also expressed in the nucleus Accumbens (nAc) where they have been implicated in the release of dopamine from the ventral… read more here.
Keywords: glycine receptors; medium spiny; spiny neurons; nucleus accumbens ... See more keywords
Nicotine-induced and D1-receptor-dependent dendritic remodeling in a subset of dorsolateral striatum medium spiny neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.05.036
Abstract: Nicotine is one of the most addictive substances known, targeting multiple memory systems, including the ventral and dorsal striatum. One form of neuroplasticity commonly associated with nicotine is dendrite remodeling. Nicotine-induced dendritic remodeling of ventral… read more here.
Keywords: nicotine; nicotine induced; spiny neurons; striatum ... See more keywords
Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons
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DOI: 10.1038/s41598-019-44798-9
Abstract: Subcellular RNAseq promises to dissect transcriptional dynamics but is not well characterized. Furthermore, FACS may introduce bias but has not been benchmarked genome-wide. Finally, D1 and D2 dopamine receptor-expressing medium spiny neurons (MSNs) of the… read more here.
Keywords: spiny neurons; biology; nucleus accumbens; medium spiny ... See more keywords
Long‐term subregion‐specific encoding of enhanced ethanol intake by D1DR medium spiny neurons of the nucleus accumbens
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DOI: 10.1111/adb.12526
Abstract: The nucleus accumbens (NAc) is a critical component of the mesocorticolimbic system and is involved in mediating the motivational and reinforcing aspects of ethanol consumption. Chronic intermittent ethanol (CIE) exposure is a reliable model to… read more here.
Keywords: long term; nac shell; medium spiny; spiny neurons ... See more keywords
Selective block of adenosine A2A receptors prevents ischaemic‐like effects induced by oxygen and glucose deprivation in rat medium spiny neurons
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15922
Abstract: Ischaemia is known to cause massive neuronal depolarization, termed anoxic depolarization (AD), due to energy failure and loss of membrane ion gradients. The neuromodulator adenosine accumulates extracellularly during ischaemia and activates four metabotropic receptors: A1,… read more here.
Keywords: a2a receptors; block adenosine; spiny neurons; medium spiny ... See more keywords
Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons
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DOI: 10.1186/s12967-024-06020-x
Abstract: Taltirelin, an orally effective thyrotropin-releasing hormone analog, significantly improves motor impairments in rat models of Parkinson's disease (PD) and enhances dopamine release within the striatum. However, the underlying mechanism remains unclear. In this study, a… read more here.
Keywords: rar; trhr; spiny neurons; taltirelin induces ... See more keywords
Exercise improves behavioral dysfunction and inhibits the spontaneous excitatory postsynaptic current of D2-medium spiny neurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1001256
Abstract: The abnormal function of striatal medium spiny neurons (MSNs) leads to the excitation-inhibition imbalance of the basal ganglia, which is an important pathogenic factor of Parkinson’s disease (PD). Exercise improves the dysfunction of basal ganglia… read more here.
Keywords: spiny neurons; excitatory postsynaptic; spontaneous excitatory; medium spiny ... See more keywords