Enduring effects of juvenile social isolation on physiological properties of medium spiny neurons in nucleus accumbens
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05284-2
Abstract: RationaleJuvenile social isolation (SI) and neglect is associated with a wide range of psychiatric disorders. While dysfunction of the corticolimbic pathway is considered to link various abnormal behaviors in SI models of schizophrenia, the enduring… read more here.
Keywords: enduring effects; social isolation; spiny neurons; physiological properties ... See more keywords
Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.08.106
Abstract: Huntington's disease (HD) is a hereditary neurodegenerative disease caused by a polyglutamine expansion within the huntingtin (HTT) gene. One of the cellular functions that is dysregulated in HD is store-operated calcium entry (SOCE), a process… read more here.
Keywords: yac128 mice; huntington disease; spiny neurons; disease ... See more keywords
Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.03.010
Abstract: The mechanisms of dopamine dysregulation syndrome (DDS) in Parkinson's disease (PD) remain unclear, although it is known that the nucleus accumbens (NAc) plays a role in its development. Based on the hypothesis that DDS and… read more here.
Keywords: dendritic spine; spiny neurons; nucleus accumbens; medium spiny ... See more keywords
High ethanol sensitive glycine receptors regulate firing in D1 medium spiny neurons in the nucleus accumbens
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107773
Abstract: Inhibitory glycine receptors (GlyRs) are widely expressed in spinal cord and brain stem. They are also expressed in the nucleus Accumbens (nAc) where they have been implicated in the release of dopamine from the ventral… read more here.
Keywords: glycine receptors; medium spiny; spiny neurons; nucleus accumbens ... See more keywords
Nicotine-induced and D1-receptor-dependent dendritic remodeling in a subset of dorsolateral striatum medium spiny neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.05.036
Abstract: Nicotine is one of the most addictive substances known, targeting multiple memory systems, including the ventral and dorsal striatum. One form of neuroplasticity commonly associated with nicotine is dendrite remodeling. Nicotine-induced dendritic remodeling of ventral… read more here.
Keywords: nicotine; nicotine induced; spiny neurons; striatum ... See more keywords
Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44798-9
Abstract: Subcellular RNAseq promises to dissect transcriptional dynamics but is not well characterized. Furthermore, FACS may introduce bias but has not been benchmarked genome-wide. Finally, D1 and D2 dopamine receptor-expressing medium spiny neurons (MSNs) of the… read more here.
Keywords: spiny neurons; biology; nucleus accumbens; medium spiny ... See more keywords
Long‐term subregion‐specific encoding of enhanced ethanol intake by D1DR medium spiny neurons of the nucleus accumbens
Sign Up to like & getrecommendations! Published in 2018 at "Addiction Biology"
DOI: 10.1111/adb.12526
Abstract: The nucleus accumbens (NAc) is a critical component of the mesocorticolimbic system and is involved in mediating the motivational and reinforcing aspects of ethanol consumption. Chronic intermittent ethanol (CIE) exposure is a reliable model to… read more here.
Keywords: long term; nac shell; medium spiny; spiny neurons ... See more keywords
Selective block of adenosine A2A receptors prevents ischaemic‐like effects induced by oxygen and glucose deprivation in rat medium spiny neurons
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15922
Abstract: Ischaemia is known to cause massive neuronal depolarization, termed anoxic depolarization (AD), due to energy failure and loss of membrane ion gradients. The neuromodulator adenosine accumulates extracellularly during ischaemia and activates four metabotropic receptors: A1,… read more here.
Keywords: a2a receptors; block adenosine; spiny neurons; medium spiny ... See more keywords
Exercise improves behavioral dysfunction and inhibits the spontaneous excitatory postsynaptic current of D2-medium spiny neurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1001256
Abstract: The abnormal function of striatal medium spiny neurons (MSNs) leads to the excitation-inhibition imbalance of the basal ganglia, which is an important pathogenic factor of Parkinson’s disease (PD). Exercise improves the dysfunction of basal ganglia… read more here.
Keywords: spiny neurons; excitatory postsynaptic; spontaneous excitatory; medium spiny ... See more keywords
Presence of Inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00228
Abstract: It is believed that the rewarding actions of drugs are mediated by dysregulation of the mesolimbic dopaminergic system leading to increased levels of dopamine in the nucleus accumbens (nAc). It is widely recognized that GABAergic… read more here.
Keywords: presence; transmission; glycinergic transmission; spiny neurons ... See more keywords
Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1107355
Abstract: Although the deubiquitinase cylindromatosis (CYLD), an abundant protein in the postsynaptic density fraction, plays a crucial role in mediating the synaptic activity of the striatum, the precise molecular mechanism remains largely unclear. Here, using a… read more here.
Keywords: dorsolateral striatum; cyld; spiny neurons; activity ... See more keywords