MicroRNA‐590‐3p inhibits trophoblast‐dependent maternal spiral artery remodeling by repressing low‐density lipoprotein receptor‐related protein 6
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.491
Abstract: The remodeling of maternal spiral artery following embryo implantation, which relies on well‐regulated trophoblast functions, is a pivotal process to ensure a successful pregnancy. Low‐density lipoprotein receptor‐related protein 6 (LRP6) and microRNAs (miRNAs, miRs) are… read more here.
Keywords: spiral artery; density lipoprotein; low density; lipoprotein receptor ... See more keywords
Fetal growth restriction is a host specific response to infection with an impaired spiral artery remodeling-inducing strain of Porphyromonas gingivalis
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DOI: 10.1038/s41598-020-71762-9
Abstract: Porphyromonas gingivalis is a periodontal pathogen implicated in a range of pregnancy disorders that involve impaired spiral artery remodeling (ISAR) with or without fetal growth restriction (FGR). Using a rodent periodontitis model, we assessed the… read more here.
Keywords: spiral artery; artery remodeling; porphyromonas gingivalis; fetal growth ... See more keywords
Porphyromonas gingivalis strain-dependent inhibition of uterine spiral artery remodeling in the pregnant rat†
Sign Up to like & getrecommendations! Published in 2018 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioy119
Abstract: Abstract Porphyromonas gingivalis (Pg) is an important periodontal pathogen that is also implicated in pregnancy complications involving defective deep placentation (DDP). We hypothesized that Pg invasion of the placental bed promotes DDP. Pregnant rats were… read more here.
Keywords: strain; porphyromonas gingivalis; spiral artery; artery remodeling ... See more keywords
Hemodynamic Consequences of Incomplete Uterine Spiral Artery Transformation in Human Pregnancy, with Implications for Placental Dysfunction and Preeclampsia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00504.2020
Abstract: Normal human pregnancy requires a dramatic increase in uteroplacental blood flow which is achieved by a transformation in the geometry of uterine spiral arteries, a key element in this blood supply system. The transformation is… read more here.
Keywords: pregnancy; spiral artery; human pregnancy; transformation ... See more keywords
Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.995462
Abstract: It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral… read more here.
Keywords: spiral artery; invasion spiral; role; trophoblast invasion ... See more keywords
Hyperglycemia disturbs trophoblast functions and subsequently leads to failure of uterine spiral artery remodeling
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1060253
Abstract: Uterine spiral artery remodeling is necessary for fetal growth and development as well as pregnancy outcomes. During remodeling, trophoblasts invade the arteries, replace the endothelium and disrupt the vascular smooth muscle, and are strictly regulated… read more here.
Keywords: spiral artery; uterine spiral; hyperglycemia disturbs; artery remodeling ... See more keywords
VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.77241
Abstract: During formation of the mammalian placenta, trophoblasts invade the maternal decidua and remodel spiral arteries to bring maternal blood into the placenta. This process, known as endovascular invasion, is thought to involve the adoption of… read more here.
Keywords: spiral artery; placental development; endovascular invasion; cadherin ... See more keywords