Directed Differentiation of Human Embryonic Stem Cells Toward Placode‐Derived Spiral Ganglion‐Like Sensory Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.16-0032
Abstract: The ability to generate spiral ganglion neurons (SGNs) from stem cells is a necessary prerequisite for development of cell‐replacement therapies for sensorineural hearing loss. We present a protocol that directs human embryonic stem cells (hESCs)… read more here.
Keywords: medicine; embryonic stem; spiral ganglion; stem ... See more keywords
Topographically Conductive Butterfly Wing Substrates for Directed Spiral Ganglion Neuron Growth.
Sign Up to like & getrecommendations! Published in 2021 at "Small"
DOI: 10.1002/smll.202102062
Abstract: Spiral ganglion neuron (SGN) degeneration can lead to severe hearing loss, and the directional regeneration of SGNs has shown great potential for improving the efficacy of auditory therapy. Here, a novel 3D conductive microstructure with… read more here.
Keywords: ganglion neuron; butterfly; topographically conductive; spiral ganglion ... See more keywords
Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0857-z
Abstract: The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the… read more here.
Keywords: hair cells; hair; mice; spiral ganglion ... See more keywords
Age-related changes in the number of cresyl-violet-stained, parvalbumin and NMDAR 2B expressing neurons in the human spiral ganglion
Sign Up to like & getrecommendations! Published in 2020 at "Hearing Research"
DOI: 10.1016/j.heares.2020.107883
Abstract: Animal-studies associate age-related hearing loss (presbycusis) with decreasing number of spiral ganglion neurons (SGNs) in Rosenthal's canal (RC) of cochlea. The excitatory neurotransmitter for SGNs is glutamate (through its receptor NMDAR 2B), which can be… read more here.
Keywords: age related; age; nmdar; number ... See more keywords
Simultaneous rather than retrograde spiral ganglion cell degeneration following ototoxically induced hair cell loss in the guinea pig cochlea
Sign Up to like & getrecommendations! Published in 2020 at "Hearing Research"
DOI: 10.1016/j.heares.2020.107928
Abstract: Severe damage to the organ of Corti leads to degeneration of the spiral ganglion cells (SGCs) which form the auditory nerve. This degeneration starts at the level of synaptic connection of the peripheral processes (PPs)… read more here.
Keywords: guinea pig; pig cochlea; simultaneous rather; spiral ganglion ... See more keywords
Myelin-induced inhibition in a spiral ganglion organ culture – Approaching a natural environment in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.05.053
Abstract: The performance of a cochlear implant depends on the defined interaction between afferent neurons of the spiral ganglion and the inserted electrode. Neurite outgrowth can be induced by neurotrophins such as brain-derived neurotrophic factor (BDNF)… read more here.
Keywords: induced inhibition; neurite outgrowth; spiral ganglion; myelin induced ... See more keywords
Tuning Surface and Topographical Features to Investigate Competitive Guidance of Spiral Ganglion Neurons.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b09258
Abstract: Cochlear Implants (CIs) suffer from limited tonal resolution due, in large part, to spatial separation between stimulating electrode arrays and primary neural receptors. In this work, a combination of physical and chemical micropatterns, formed on… read more here.
Keywords: ganglion neurons; tuning surface; surface topographical; spiral ganglion ... See more keywords
3D Ti3C2Tx MXene–Matrigel with Electroacoustic Stimulation to Promote the Growth of Spiral Ganglion Neurons
Sign Up to like & getrecommendations! Published in 2022 at "ACS Nano"
DOI: 10.1021/acsnano.2c06306
Abstract: Cochlear implantation has become the most effective treatment method for patients with profound and total hearing loss. However, its therapeutic efficacy is dependent on the number and normal physiological function of cochlear implant-targeted spiral ganglion… read more here.
Keywords: cochlear implant; ganglion neurons; mxene matrigel; ti3c2tx mxene ... See more keywords
In Vivo Electrocochleography in Hybrid Cochlear Implant Users Implicates TMPRSS3 in Spiral Ganglion Function
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32630-9
Abstract: Cochlear implantation, a surgical method to bypass cochlear hair cells and directly stimulate the spiral ganglion, is the standard treatment for severe-to-profound hearing loss. Changes in cochlear implant electrode array design and surgical approach now… read more here.
Keywords: cochlear implant; hearing; electrocochleography; spiral ganglion ... See more keywords
Specification of neuronal subtypes in the spiral ganglion begins prior to birth in the mouse
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203935119
Abstract: Significance Spiral Ganglion neurons (SGNs) are responsible for relaying complex sound information from the cochlea to the auditory brainstem, and their loss contributes to age-related and acquired hearing loss. Physiological, anatomical, and molecular approaches have… read more here.
Keywords: ganglion; subtypes spiral; spiral ganglion; specification neuronal ... See more keywords
ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207433119
Abstract: A cardinal feature of the auditory pathway is frequency selectivity, represented in a tonotopic map from the cochlea to the cortex. The molecular determinants of the auditory frequency map are unknown. Here, we discovered that… read more here.
Keywords: auditory pathway; auditory; cochlea; spiral ganglion ... See more keywords