Synthesis, anticancer and antibacterial evaluation of novel spiramycin-acylated derivatives
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DOI: 10.1039/d4ra03126a
Abstract: Spiramycin and its derivatives are commonly used antimicrobials, and its derivative, carrimycin, has recently been found to have good anticancer potential. Here, we found that the 4′′-OH of spiramycin can be selectively acylated, resulting in… read more here.
Keywords: novel spiramycin; spiramycin derivatives; synthesis anticancer; anticancer antibacterial ... See more keywords
Uncovering Anticancer Mechanisms of Spiramycin Derivatives Using Transcriptomic and Metabolomic Analyses
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DOI: 10.3390/metabo15100647
Abstract: Background: Carrimycin is a mixture of spiramycin derivatives with antibacterial functions. However, recent studies have shown that it possesses certain anticancer properties. The specific mechanism of the anticancer activity is unknown. Methods: To study the… read more here.
Keywords: uncovering anticancer; anticancer; spiramycin derivatives; mechanism ... See more keywords