Melatonin pharmacophoric motifs in the anancomeric spiranic oxindole-cycloalkane scaffold: Theoretical and 1H NMR conformational analysis
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DOI: 10.1016/j.molstruc.2019.127267
Abstract: Abstract N-[2′-oxospiro(cycloalkane-1,3′-indoline)methyl]acetamides (1a/b-4a/b), analogues conformationally restricted of neurohormone melatonin (MLT), were constructed through pharmacophoric ethylacetamido side chain incorporation into a chiral spiro-ring structure. A facile synthetic route was established to afford the epimeric spirocycloalkane pairs… read more here.
Keywords: analysis; conformational analysis; cycloalkane scaffold; spiranic oxindole ... See more keywords