Synthesis and SARs study of novel spiro-oxindoles as potent antiproliferative agents with CDK-2 inhibitory activities.
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300185
Abstract: A series of 16 novel spirooxindole analogs 8a-p were designed and constructed via cost-effective single-step multicomponent [3+2] cycloaddition reaction of azomethine ylide (AY) generated in situ from substituted isatin (6a-d) with suitable amino acids (7a-c)… read more here.
Keywords: mcf; novel spiro; synthesis sars; sars study ... See more keywords
Novel synthetic approach to non-natural conformationally rigid spiro-linked amino acids
Sign Up to like & getrecommendations! Published in 2019 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-019-2452-0
Abstract: Abstract1-Aminospiro[2.3]hexane-1,5-dicarboxylic and 1-ammo-5-(ammomethyl)spiro[2.3]hexane-1-carboxylic acids, which are the conformationally rigid analogues of glutamic acid and lysine, respectively, were synthesized from 3-methylidenecyclobutanecarbonitrile. The synthetic route includes a catalytic [1+2]-cycloaddition of ethyl 2-diazo-2-nitroacetate to a double bond of… read more here.
Keywords: novel synthetic; non natural; spiro; approach non ... See more keywords
The synthesis and thermal properties of fluorodioxy-substituted N,N-spiro bridged cyclotriphosphazenes
Sign Up to like & getrecommendations! Published in 2017 at "Polyhedron"
DOI: 10.1016/j.poly.2017.01.014
Abstract: Abstract Fluorodioxy substituted mono-spiro ( 1a , b ), di-spiro ( 2a , b ) and mono-ansa ( 3a – c ) cyclotriphosphazene derivatives were reacted with n -butylamine to obtain fluorodioxy cyclotriphosphazenes bearing a… read more here.
Keywords: synthesis thermal; spiro; thermal properties; fluorodioxy substituted ... See more keywords
A facile one pot C-C and C-N bond formation for the synthesis of spiro-benzodiazepines and their cytotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.10.060
Abstract: Abstract An efficient, multicomponent and environmentally benign protocol has been developed for the synthesis of spiro-benzodiazepines through C C and C N bond formations in a single step. This one-pot protocol proceeds via three component… read more here.
Keywords: bond; spiro; spiro benzodiazepines; one pot ... See more keywords
Phosphotungstic acid mediated, microwave assisted solvent-free green synthesis of highly functionalized 2ˈ-spiro and 2, 3-dihydro quinazolinone and 2-methylamino benzamide derivatives from aryl and heteroaryl 2-amino amides
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.12.011
Abstract: Abstract Phosphotungstic acid has been found as green catalyst for the synthesis of spiro and cyclized quinazolinones and 2-amino substituted carboxamide under microwave irradiation and solvent-free condition has been developed. The scope of the reaction… read more here.
Keywords: synthesis; phosphotungstic acid; benzamide; spiro ... See more keywords
Isatins 3-C annulation vs ring-opening: Two different pathways for synthesis of spiro compounds via multicomponent reactions
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151181
Abstract: Abstract An efficient synthesis of spiro compounds via two different pathways from the reactions of isatins, 3-phenylisoxazol-5(4H)-one (3-ethylisoxazol-5(4H)-one), and pyrazol-5-amine (6-aminopyrimidine-2,4(1H,3H)-dione) were reported. The catalyst Amberlyst-15 could be easy recycled and reused for many time… read more here.
Keywords: different pathways; spiro; spiro compounds; compounds via ... See more keywords
Spiro Derivatives in the Discovery of New Pesticides: A Research Review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02301
Abstract: Spiro compounds are biologically active organic compounds with unique structures, found in a wide variety of natural products and drugs. They do not readily lead to drug resistance due to their unique mechanisms of action… read more here.
Keywords: new pesticides; spiro compounds; derivatives discovery; discovery new ... See more keywords
Chartspiroton, a Tetracyclic Spiro-naphthoquinone Derivative from a Medicinal Plant Endophytic Streptomyces.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00696
Abstract: A novel 6/6/5/6 tetracyclic polyketide named chartspiroton (1) was isolated from a medicinal plant endophytic Streptomyces in Dendrobium officinale. The complete structure assignment with absolute stereochemistry was elucidated through spectroscopic data, computational calculations, and single-crystal… read more here.
Keywords: plant endophytic; endophytic streptomyces; spiro; naphthoquinone derivative ... See more keywords
Circularly Polarized Luminescence from Chiral Spiro Molecules: Synthesis and Optical Properties of 10,10'-Spirobi(indeno[1,2-b][1]benzothiophene) Derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02337
Abstract: Chiral spiro polycyclic aromatic compounds with thiophene and/or thiophene S,S-dioxide units were synthesized as a new family of circularly polarized luminescence (CPL) materials. Oxidation of the thiophene unit to its S,S-dioxide provided significant changes in… read more here.
Keywords: luminescence chiral; circularly polarized; chiral spiro; spiro ... See more keywords
Challenges for Thermally Stable Spiro-MeOTAD toward the Market Entry of Highly Efficient Perovskite Solar Cells.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c21852
Abstract: Perovskite solar cells (PSCs) have drawn great attention because they have seen a dramatic increase in power conversion efficiency (PCE) over only a decade and reached 25.5% of certified PCE in 2021. The efficiency competitiveness… read more here.
Keywords: challenges thermally; solar cells; spiro meotad; stability ... See more keywords
Circularly Polarized Thermally Activated Delayed Fluorescence Emitters in Through-Space Charge Transfer on Asymmetric Spiro Skeletons.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c08980
Abstract: This work describes a strategy to produce circularly polarized thermally activated delayed fluorescence (CP-TADF). A set of two structurally similar organic emitters SFST and SFOT are constructed, whose spiro architectures containing asymmetric donors result in… read more here.
Keywords: polarized thermally; thermally activated; circularly polarized; spiro ... See more keywords