Synthesis of 1,3-diaryl-spiro[azetidine-2,3′-indoline]-2′,4-dionesviathe Staudinger reaction:cis- ortrans-diastereoselectivity with different addition modes
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DOI: 10.1039/d0ra02374d
Abstract: A new synthetic approach for realizing biologically relevant bis-aryl spiro[azetidine-2,3′-indoline]-2′,4-diones was developed based on Staudinger ketene–imine cycloaddition through the one-pot reaction of substituted acetic acids and Schiff bases in the presence of oxalyl chloride and… read more here.
Keywords: azetidine indoline; spiro azetidine; spiro; reaction ... See more keywords