Design and Synthesis of Novel Spiro [Chromane‐2,4'‐Piperidin]‐4‐one Derivatives: Anti‐proliferative Investigation and Molecular Docking Studies
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DOI: 10.1002/ajoc.202400604
Abstract: Chemists around the globe are extensively working for remedial solutions to cancer, one of the greatest health hazards. We have synthesized twenty‐three novel spiro [chromane‐2,4'‐piperidin]‐ 4 ‐one derivatives (KBS and KMS series of analogues) as… read more here.
Keywords: chromane piperidin; molecular docking; spiro chromane; piperidin one ... See more keywords
Dearomatization of 3-Aminophenols for Synthesis of Spiro[chromane-3,1′-cyclohexane]-2′,4′-dien-6′-ones via Hydride Transfer Strategy-Enabled [5+1] Annulations
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DOI: 10.3390/molecules29051012
Abstract: The Sc(OTf)3-catalyzed dearomative [5+1] annulations between readily available 3-aminophenols and O-alkyl ortho-oxybenzaldehydes were developed for synthesis of spiro[chromane-3,1′-cyclohexane]-2′,4′-dien-6′-ones. The “two-birds-with-one-stone” strategy was disclosed by the dearomatization of phenols and direct α-C(sp3)–H bond functionalization of oxygen… read more here.
Keywords: spiro chromane; dien ones; chromane cyclohexane; hydride transfer ... See more keywords
Diastereoselective Synthesis and Biological Evaluation of Spiro[chromane-2,4′-pyrimidin]-2′(3′H)-ones as Novel Antimicrobial and Antioxidant Agents
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DOI: 10.3390/molecules30142954
Abstract: This study reports an improved diastereoselective synthesis of substituted spiro[chromane-2,4′-pyrimidin]-2′(3′H)-ones via the acid-catalyzed condensation of 6-styryl-4-aryldihydropyrimidin-2-ones with resorcinol, 2-methylresorcinol, and pyrogallol. The optimized method allows for the isolation of diastereomerically pure products, with stereoselectivity controlled… read more here.
Keywords: pyrimidin ones; diastereoselective synthesis; chromane pyrimidin; spiro chromane ... See more keywords